Conversion of Labor Analgesia for Intrapartum Cesarean Delivery: DPE v CSE v Epidural
NCT ID: NCT05514431
Last Updated: 2025-08-17
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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ENROLLING_BY_INVITATION
1500 participants
OBSERVATIONAL
2017-02-01
2026-07-31
Brief Summary
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Detailed Description
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From this list, patients that had cesarean delivery with an epidural catheter will be identified and split into three groups based on the type of neuraxial block listed in the block document of the patient's medical record:
Group 1 - Dural puncture epidural Group 2 - Epidural Group 3 - Combined spinal-epidural
Failure of epidural catheter conversion to surgical anesthesia at cesarean delivery will be defined by requirement of a second anesthetic at the time of surgery, including spinal or repeat epidural techniques or general anesthesia at the time of cesarean delivery
Data Collection: All data will be collected retrospectively from the electronic medical record.
1. Type of neuraxial block
2. Size of needle used for DPE or CSE: 25 g or 27 g
3. Duration of time from epidural placement until CD (Time of epidural placement; time of delivery)
4. Number of epidural top-ups
5. Type and amount of medication used for conversion to surgical anesthesia
6. Urgency of cesarean delivery
7. Airway documentation indicative of general anesthesia (if applicable)
8. Length (time) of surgical procedure
Other data collected from patient electronic records will include:
1. Maternal demographics: Parity, number of prior cesarean deliveries, weight, height, BMI
2. Fetal characteristics (birthweight, Apgar scores)
3. Indication for cesarean delivery
1. Fetal distress (NRFHT, fetal intolerance of labor)
2. Failure of labor (Failure to dilate, failure to descend)
3. Failed operative vaginal delivery
4. Maternal comorbidity
5. Emergency (cord prolapse, abruption, uterine rupture)
4. Anesthesiologist (Fellowship trained: Y/N) at time of cesarean delivery
Conditions
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Study Design
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COHORT
RETROSPECTIVE
Study Groups
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Dural puncture epidural (DPE)
Subjects that received neuraxial labor analgesia of dural puncture epidural for intrapartum cesarean delivery
Dural Puncture Epidural (DPE) technique
Epidural catheters placed via DPE technique
Combined spinal epidural (CSE)
Subjects that received neuraxial labor analgesia of combined spinal epidural for intrapartum cesarean delivery
Combined Spinal-Epidural (CSE) technique
Epidural catheters placed via CSE technique
Traditional Epidural
Subjects that received neuraxial labor analgesia of epidural for intrapartum cesarean delivery
Epidural
Traditional epidural catheter placement
Interventions
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Epidural
Traditional epidural catheter placement
Dural Puncture Epidural (DPE) technique
Epidural catheters placed via DPE technique
Combined Spinal-Epidural (CSE) technique
Epidural catheters placed via CSE technique
Eligibility Criteria
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Inclusion Criteria
2. Singleton gestation
Exclusion Criteria
2. Inadvertent dural puncture
FEMALE
Yes
Sponsors
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University of British Columbia
OTHER
Mayo Clinic
OTHER
Responsible Party
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Emily E. Sharpe, M.D.
Principal Investigator
Principal Investigators
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Emily Sharpe, MD
Role: PRINCIPAL_INVESTIGATOR
Mayo Clinic
Locations
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Mayo Clinic
Rochester, Minnesota, United States
BC Women's Hospital
Vancouver, British Columbia, Canada
Countries
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Related Links
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Mayo Clinic Clinical Trials
Other Identifiers
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20-004677
Identifier Type: -
Identifier Source: org_study_id
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