Wound Infiltration as Part of an Opioid Free Pain Management Pathway Following Cesarean Delivery

NCT ID: NCT03545516

Last Updated: 2018-08-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE2

Total Enrollment

540 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-09-17

Study Completion Date

2018-11-01

Brief Summary

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This study will investigate the effect of three types of wound infiltration on post Cesarean opioid analgesia consumption when used in conjunction with an opioid free postoperative analgesia pathway.

Detailed Description

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The subjects that meet the inclusion criteria of the study will be randomized preoperatively into three arms following a 1:1:1 ratio. During the intraoperative course one of three combinations of wound infiltration will be administered to subjects prior to the closure of the surgical incision. Subjects in Group I will receive a placebo of normal saline. Subjects in Group II will receive bupivacaine alone. Subjects in Group III will receive both bupivacaine and dexmedetomidine.

Conditions

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Pain, Postoperative Anesthesia, Local Opioid Use

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Caregivers Investigators

Study Groups

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Placebo

Wound infiltration with a placebo

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Injection of a placebo into the surgical wound

Bupivacaine

Wound Infiltration with 20 mL (150mg) of 0.75% bupivacaine diluted with 5 mL of normal saline to give a 25 mL

Group Type EXPERIMENTAL

Bupivacaine

Intervention Type DRUG

Injection of bupivacaine into the surgical incision prior to its closure.

Bupivacaine and Dexmedetomidine

Wound Infiltration with 20 mL (150mg) of 0.75% bupivacaine and 1.5 mcg/kg of dexmedetomidine will be diluted with normal saline to make 25 mL of solution .

Group Type EXPERIMENTAL

Bupivacaine

Intervention Type DRUG

Injection of bupivacaine into the surgical incision prior to its closure.

Dexmedetomidine

Intervention Type DRUG

Injection of dexmedetomidine ( an adjuvant) into the surgical incision prior to its closure.

Interventions

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Bupivacaine

Injection of bupivacaine into the surgical incision prior to its closure.

Intervention Type DRUG

Dexmedetomidine

Injection of dexmedetomidine ( an adjuvant) into the surgical incision prior to its closure.

Intervention Type DRUG

Placebo

Injection of a placebo into the surgical wound

Intervention Type DRUG

Other Intervention Names

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Bupivacaine wound infiltration Dexmedetomidine wound infiltration

Eligibility Criteria

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Inclusion Criteria

* All scheduled Cesarean deliveries with intrathecal or epidural anesthesia

Exclusion Criteria

* Emergency Cesarean deliveries
* Multifetal gestation
* Subjects \<18 years old
* Subjects belonging to a vulnerable population (including subjects with a known opioid addiction, subjects with a history of mental illness and prisoners)
* Cesarean delivery with general anesthesia
* Known allergy or hypersensitivity to any of the study medications
* Subjects that can't comprehend the visual analog scale for quantitative pain assessment
Minimum Eligible Age

18 Years

Maximum Eligible Age

55 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Richmond University Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Nisha Lakhi, MD

Research Director

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Nisha Lakhi, MD

Role: PRINCIPAL_INVESTIGATOR

Richmond University Medical Center

Locations

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Richmond University Medical Center

Staten Island, New York, United States

Site Status

Countries

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United States

Central Contacts

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Nisha Lakhi, MD

Role: CONTACT

718-818-2109

Other Identifiers

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Post Cesarean Pain Management

Identifier Type: -

Identifier Source: org_study_id

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