Evaluation of HRCT Patterns in Systemic Sclerosis-associated Interstitial Lung Disease

NCT ID: NCT05482607

Last Updated: 2024-08-27

Basic Information

• Recruitment Status: RECRUITING
• Total Enrollment: 100 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2023-01-01
• Study Completion Date: 2025-10-01

Brief Summary

Systemic sclerosis (SSc) is a heterogeneous systemic autoimmune disease with distinct prognosis according to patients. Interstitial lung disease (ILD) concerns almost 50 % of SSc patients and represents the main cause of mortality. SSc-ILD is variable: from limited forms (with asymptomatic patients) to extensive lesions. Disease course in SSc-ILD is also highly variable: patients can experience stable disease, slow or fast progression. Investigators performed unsupervised clustering analysis to classify SSc-ILD according to elementary radiological lesions on HRCT scan.

Conditions

Systemic Sclerosis; Interstitial Lung Disease

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: RETROSPECTIVE

Study Groups

SSc-ILD patients

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• Patients with systemic sclerosis according to 2013 ACR/EULAR criteria
• Patients with interstitial lung disease on HRCT chest

Exclusion Criteria

• Patients with an alternative diagnosis of SSc-associated ILD (silicosis, sarcoidosis, lung cancer or other significant lung abnormalities)

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Central Hospital, Nancy, France

OTHER

Sponsor Role: lead

Responsible Party

Paul DECKER, MD

Principal Investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Paul Decker, MD

Role: PRINCIPAL_INVESTIGATOR

CHU NANCY

Locations

Central Hospital

Nancy, , France

Site Status: RECRUITING

Countries

France

Central Contacts

Paul DECKER, MD

Role: CONTACT

p.decker@chru-nancy.fr

+33383157240

Facility Contacts

Paul DECKER, MD

Role: primary

decker.paul57130@gmail.com

Other Identifiers

2022PI105

Identifier Type: -

Identifier Source: org_study_id