Evaluation of the Reproducibility of the Automated Measurement of the Extent of ILD on Chest CT
NCT ID: NCT06743022
Last Updated: 2026-01-02
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
150 participants
INTERVENTIONAL
2025-06-24
2026-09-30
Brief Summary
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Therefore, the purpose of this study is to evaluate the variability of automated ILD quantification on chest CT. Reproducibility will be assessed by repeating chest CT scans and using different tools to measure the extent of disease.
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Detailed Description
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An advantage of automated scoring methods is that they theoretically offer perfect repeatability of measurement. However, this is only true if the measurement is repeated on the same images. Several parameters can alter the appearance of the lungs on scanner images, such as the degree of inspiration or the reconstruction kernel used to reconstruct the images. There is a lack of data on the reproducibility of the whole process of automated ILD quantification and therefore its accuracy.
Therefore, the purpose of this study is to evaluate the variability of automated ILD quantification on chest CT.
Reproducibility will be assessed by repeating chest CT scans and using different tools to measure the extent of disease in patients with ILD from 2 institutions. Chest CT will be repeated the same day. This will allow assessment of the variability of automated measurement of ILD extent between 2 CT scans performed on the same day and when using different software. It will also allow to assess the variability of lung volume between the 2 CT scans and the effect of disease (idiopathic pulmonary fibrosis or connective tissue disease-related ILD) on the reproducibility of ILD quantification.
Conditions
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Study Design
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NA
SINGLE_GROUP
OTHER
NONE
Study Groups
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Patients with interstitial lung disease
Chest CT
Repeated chest CT for automated ILD quantification
Interventions
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Chest CT
Repeated chest CT for automated ILD quantification
Eligibility Criteria
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Inclusion Criteria
* Known interstitial lung disease as part of idiopathic pulmonary fibrosis or connective tissue disease
* Followed in one of the participating hospitals
* Requiring a chest CT as part of a scheduled assessment
* Affiliated to a French national social security
* Informed consent
Exclusion Criteria
* Pregnancy
* Inability to hold an apnea for 10 seconds
* Patients in the exclusion period after a previous research
* Need for additional procubitus or expiratory images
18 Years
ALL
No
Sponsors
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URC-CIC Paris Descartes Necker Cochin
OTHER
Assistance Publique - Hôpitaux de Paris
OTHER
Responsible Party
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Principal Investigators
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Guillaume CHASSAGNON, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
Cochin Hospital - AP-HP
Locations
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APHP - Bichat hospital - Radiology
Paris, IDF, France
APHP - Bichat hospital - Rheumatology
Paris, IDF, France
APHP - Cochin Hospital - Internal medicine
Paris, IDF, France
APHP - Cochin Hospital - Pneumology
Paris, IDF, France
APHP - Cochin Hospital - Radiology
Paris, IDF, France
APHP - Bichat Hospital - Pneumology
Paris, IDF, France
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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2024-A01384-43
Identifier Type: OTHER
Identifier Source: secondary_id
APHP240783
Identifier Type: -
Identifier Source: org_study_id
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