Assessment of Lung Movement With Computed Tomography (CT)

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

25 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-07-01

Study Completion Date

2018-10-31

Brief Summary

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The purpose of this study is to determine whether patient with ILD have altered lung compliance on chest CT before they have macroscopic structural changes on CT.

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Detailed Description

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Interstitial lung disease (ILD) is a group of lung disorders in which the lung tissues become inflamed and then damaged. Idiopathic Pulmonary Fibrosis (IPF) is one of the subtypes of ILD which has characteristic histological and CT features. It is well known that microscopic fibrosis occurs in the lungs of IPF patients well before the structural changes of fibrosis become apparent on CT. By combining sophisticated image analysis with CT scans obtained at full inspiration and full expiration, it may be possible to detect earlier changes of IPF than currently possible by looking at macro structural features alone. With the recent development of new therapeutics for IPF, early detection of the disease and improved monitoring of treatment efficacy will become important. Using CT to assess regional lung compliance has the potential to become an easily translated clinical tool.

Conditions

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Interstitial Lung Disease

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

All participants will undergo CT and pulmonary function testing.

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Pulmonary Assessment

All participants will undergo a Chest CT scan and pulmonary function testing

Group Type OTHER

Chest CT

Intervention Type DEVICE

Inspiration and expiration chest CT

Pulmonary Function Testing

Intervention Type DIAGNOSTIC_TEST

Measure lung function

Interventions

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Chest CT

Inspiration and expiration chest CT

Intervention Type DEVICE

Pulmonary Function Testing

Measure lung function

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Subjects with ILD: Subjects must have a physician diagnosis of ILD and be in stable pulmonary condition at the time of the CT
* Healthy subjects: Subjects must have no history of pulmonary disease and smoked less than 100 cigarettes in their lifetime