HR Chest CT Visual Scoring, Spirometry and Health Related Quality of Life in Evaluating Severity of ILD Patients

NCT ID: NCT05999838

Last Updated: 2023-08-21

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 50 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2023-10-31
• Study Completion Date: 2025-02-28

Brief Summary

To establish a simplified approach for assessment of severity of interstitial lung disease by evaluating the relationship between HRCT findings, the clinical severity score,spirometry and quality of life.

Detailed Description

The interstitial lung diseases are a group of parenchymal pulmonary disorders that affect the interstitium causing progressive fibrosis of lung tissue. These disorders characterized by dyspnea aggravated by exertion . This group of diseases is associated with substantial morbidity and mortality. Thus, a multi-disciplinary approach including clinical, pathological, and radiological correlation is required to reach accurate assessment. The high-resolution computed tomography [HRCT] images of the chest are considered the main platform for the diagnostic approach .High-resolution CT (HRCT) scans offer the possibility of measuring disease severity more accurately and sensitively by focusing on fibrotic changes. HRCT images illustrate the presence and extent of parenchymal abnormalities including: reticular opacities, ground-glass opacities, traction bronchiectasis and honeycombing. Most patients with suspected ILDs are likely to undergo complete Pulmonary Function Testing. Usually there is restrictive pulmonary function with decreased TLC (Total Lung Capacity) , FVC (Forced Vital Capacity), FEV1 (Forced Expiratory Volume in One Second) and a normal or increased FEV1/FVC ratio.

Conditions

Interstitial Lung Disease

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: CROSS_SECTIONAL

Interventions

HRCT chest visual scoring

CT-based semi-quantitative scoring will be calculated according to number of lung segments affected on both sides.

The finding on each segment will be given a score from 1 to 4 as follows:

1. for ground glass opacities.

2. for reticulations and fibrotic changes.

3. for bronchiectatic changes.

4. for honeycombing and sub-pleural cysts.

Intervention Type: DIAGNOSTIC_TEST

Other Intervention Names

spirometry

Eligibility Criteria

Inclusion Criteria

• All patients admitted at Chest Department or presented to our out patient clinic with clinical diagnosis of Interstitial Lung Diseases among both sexes

Exclusion Criteria

• patients under 18 years old.
• pregnant patients.
• patients with a history of previous lung resections.
• presence of bronchial carcinoma or lobar consolidation.
• patients contraindicated to perform pulmonary function will be excluded.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Assiut University

OTHER

Sponsor Role: lead

Responsible Party

Dina Wageeh Fahim

Doctor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Central Contacts

Dina W. Fahim, resident doctor

Role: CONTACT

tinawageh0@gmail.com

01287799134

Nermeen M. Abu Elkassem, Lecturer

Role: CONTACT

nermenabuelkassem@gmail.com

01000767713

Other Identifiers

HR chest CT spirometry ILD

Identifier Type: -

Identifier Source: org_study_id