Quantitative Study on HRCT Phenotype of COPD

NCT ID: NCT04953611

Last Updated: 2021-07-08

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 150 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2013-07-01
• Study Completion Date: 2014-11-30

Brief Summary

To explore the HRCT phenotype of the combined COPD assessment staging system

Detailed Description

HRCT can be rapidly and safely deployed has enabled COPD research to move beyond FEV1 by facilitating and amplifying clinical phenotyping measurements, providing quantitative information, and detecting significant responses to therapy even in the absence of significant FEV1 improvements.

We explore the HRCT phenotype of the combined COPD assessment staging system,and found that:

1. Airway remodeling occurs in COPD patients. CT shows varying degrees of bronchial wall thickness, area increasing and emphysema as the new GOLD classification Group A-D arising.

2. The GOLD Combined assessment staging system helps doctors choose an individualized treatment for the COPD patients

Conditions

Chronic Obstructive Pulmonary Disease

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

Group A in GOLD

CAT\<10、mMRC 0-1、FEV1%≥50%、the frequency of acute exacerbations in the past year\<2；

No interventions assigned to this group

Group B in GOLD

CAT≥10、mMRC≥2、FEV1%≥50%、the frequency of acute exacerbations in the past year\<2

No interventions assigned to this group

Group C in GOLD

CAT\<10、mMRC 0-1、 FEV1%\<50%、the frequency of acute exacerbations in the past year≥2 or leading to hospital admission≥1

No interventions assigned to this group

Group D in GOLD

CAT≥10、mMRC≥2、FEV1%\<50%、the frequency of acute exacerbations in the past year≥2 or leading to hospital admission≥1

No interventions assigned to this group

Control Group

not COPD

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

1. Age between 40 and 80 (including 40 and 80)

2. It meets the diagnostic criteria for COPD

3. No language communication barriers, or the family members who know the condition can complete the questionnaire on behalf of the patient, and the data are reliable;

4. Voluntarily agree to participate in this study

Exclusion Criteria

1. Older than 80 or younger than 40

2. Pregnant women

3. Complicating with other lung diseases, such as asthma, pneumonia, bronchiectasis, lung abscess, interstitial lung disease, confirmed and suspected lung cancer of lung shadow, active pulmonary tuberculosis, etc

4. Previous lung surgery

5. Cognitive dysfunction

6. Unable to cooperate with lung function test.

• Minimum Eligible Age: 40 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Peking University Third Hospital

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Peking University Third Hospital

Beijing, , China

Countries

China

Other Identifiers

2013116

Identifier Type: -

Identifier Source: org_study_id