Role of MSCT of Chest in Differentiation Between COPD Patients According to Their Smoking Status

NCT ID: NCT05475977

Last Updated: 2022-08-02

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 90 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2022-08-31
• Study Completion Date: 2023-07-31

Brief Summary

Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality all over the world. Smoking is considered as an important risk factor, but other risk factors are present. Around 30 % of patients with COPD are non-smokers.

Cessation of smoking in patients with COPD causes decreases the presence of micronodules and other criteria of CT chest.

In last few years, some researchers reported that cessation of smoking raise the apparent extent of emphysema. The cause is not obvious, but this paradoxical fall in lung density is thaught to be resulting from decrease in inflammation after smoking cessation.

CT chest criteria of COPD in active smokers, non-smokers and ex-smokers seem to be different.

So, comparison between CT chest Criteria of COPD in smokers, ex-smokers and non-smokers will be searched in this study to detect the role of multislice computed tomography (MSCT) chest in differentiation between COPD patients according to their smoking status.

Detailed Description

Basic ethical principles of medical research; beneficence (do well), non-maleficence (do no harm), respect and distributive justice were implemented. The study will be carried out in accordance with the Declaration of Helsinki and the principles of good clinical practice.

Conditions

Patient Participation

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

First Group

Thirty patients of COPD smokers patients.

MSCT chest

Intervention Type: DIAGNOSTIC_TEST

Multi slice Computed Tomography of the chest

Second group

Thirty patients of COPD ex-smokers patients.

MSCT chest

Intervention Type: DIAGNOSTIC_TEST

Multi slice Computed Tomography of the chest

Third group

Thirty patients of COPD non-smokers patients.

MSCT chest

Intervention Type: DIAGNOSTIC_TEST

Multi slice Computed Tomography of the chest

Interventions

MSCT chest

Multi slice Computed Tomography of the chest

Intervention Type: DIAGNOSTIC_TEST

Eligibility Criteria

Inclusion Criteria

1. All patients with chronic obstructive Pulmonary Disease.

2. Patients above 18 years.

Exclusion Criteria

1. Patients with unclear smoking history.

2. Patients with active pneumonia.

3. Patients with acute COPD exacerbation.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Somaia Ahmad AbdAllah Ahmad

OTHER

Sponsor Role: lead

Responsible Party

Somaia Ahmad AbdAllah Ahmad

Main investigator

Responsibility Role: SPONSOR_INVESTIGATOR

Principal Investigators

Somaia Ahmad AbdAllah Ahmad, M.B.B.Ch

Role: PRINCIPAL_INVESTIGATOR

Assiut University

Central Contacts

Somaia Ahmad AbdAllah Ahmad, M.B.B.Ch

Role: CONTACT

somayaahmad64@gmail.com

01024833938

Other Identifiers

Somaia Ahmad

Identifier Type: -

Identifier Source: org_study_id