Mechanisms of COPD Exacerbation Recurrence

NCT ID: NCT04024735

Last Updated: 2019-07-18

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 166 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2019-06-01
• Study Completion Date: 2022-05-01

Brief Summary

Chronic obstructive pulmonary disease (COPD) is a common smoking-related lung disease. Patients with COPD are at increased risk of readmission to hospitals within the following 30 days. Hospital readmissions of COPD contribute to clinical and economic burden on society. Understanding why some COPD patients are readmitted remains a key area of unmet need.

To our knowledge, no previous study has fully investigated both the social and clinical risk factors associated with these types of patients. The investigators want to prospectively and comprehensively explore the possible causes, whether clinical or social factors, that cause rehospitalisation. The investigators will be collecting demographic and clinical information including daily physical activity level, lung function, blood and sputum samples. These measurements will be collected at patient admission, discharge and at follow-up of 30 and 90 days. This process could lead to a better understanding of the reasons which prevent early hospital readmission for those patients.

Conditions

Pulmonary Disease, Chronic Obstructive; COPD Exacerbation; Patient Readmission; Recurrence

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Interventions

Spirometry, Forced Oscillation Technique, Step-counter, sputum and blood samples

We will be collecting demographic and clinical information including daily physical activity level, lung function, blood and sputum samples. These measurements will be collected at patient admission, discharge and at follow-up of 30 and 90 days.

Intervention Type: DIAGNOSTIC_TEST

Eligibility Criteria

Inclusion Criteria

• Patients who have a primary diagnosis of COPD
• Patients admitted to hospital with an exacerbation.

Exclusion Criteria

• Patients in whom an initial diagnosis of an AECOPD is revised to an alternative at a later phase of the study.
• Patients who have a predominant history of asthma
• Patients with a confirmed active malignancy
• Patients who have a predominant history of bronchiectasis.
• Cognitive impairment patients with a Mental Test Score (MTS) of 6 or less.
• Inability to give informed consent to take part in the study

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

University College, London

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Royal Free Hospital NHS

London, , United Kingdom

Site Status: RECRUITING

Countries

United Kingdom

Facility Contacts

Jaber S Alqahtani, MSc

Role: primary

jaber.alqahtani.18@ucl.ac.uk

+447846713703

Other Identifiers

21022

Identifier Type: -

Identifier Source: org_study_id