Oxidative Stress Markers in COPD

NCT ID: NCT04748887

Last Updated: 2021-02-10

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 70 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2018-09-01
• Study Completion Date: 2019-09-01

Brief Summary

Background:Striking feature of Chronic obstructive pulmonary disease (COPD) is its inability to resolve after cigarette smoke exposure has ended, which has contributed to the possibility that the disease could also be driven by other endogenous causes, such as autoimmunity or chronic infection . Many of the pathogenetic pathways involved in COPD and its development tend to be driven by oxidative stress.

Conditions

Role of Oxidative Stress in COPD

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

nonsmokers copd cases ,

Fourty subjects of COPD who are non-smokers or stopped smoking for more than 6 months

oxidative stess markers

Intervention Type: OTHER

markers of oxidative stress , Superoxide Dismutase (SOD) and Malondialdehyde (MDA) by ( ELISA Kit SinoGeneClon Biotech Co.,Ltd Catalog No : SG- 10188) .

non smokers healthy control

Thirty subjects of non smokers healthy control

oxidative stess markers

Intervention Type: OTHER

markers of oxidative stress , Superoxide Dismutase (SOD) and Malondialdehyde (MDA) by ( ELISA Kit SinoGeneClon Biotech Co.,Ltd Catalog No : SG- 10188) .

Interventions

oxidative stess markers

markers of oxidative stress , Superoxide Dismutase (SOD) and Malondialdehyde (MDA) by ( ELISA Kit SinoGeneClon Biotech Co.,Ltd Catalog No : SG- 10188) .

Intervention Type: OTHER

Other Intervention Names

Superoxide Dismutase (SOD) and Malondialdehyde (MDA)

Eligibility Criteria

Inclusion Criteria

• 1-Forty subjects of COPD who are non-smokers or stopped smoking for more than 6 months Based on the Global Initiative for Chronic Obstructive Lung Disease guidelines, COPD was diagnosed.9 2- Thirty subjects of non smokers healthy control

Exclusion Criteria

• Patients of:

1. Acute exacerbation, at the time of the study, of COPD.

2. Any obvious abnormal lung parenchymal lesions.

3. Lung cancer.

4. Congestive heart failure.

5. current smokers

6. Drugs e.g anti-inflammatory , steroids ,analgesics, insulin , antineoplastic, antipsychotic drugs in the previous 2 weeks before the study.

• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Minia University

OTHER

Sponsor Role: lead

Responsible Party

zainab hassan saeed

principle investigator ,faculty of medicine,department of chest diseases,Minia University

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

zainab H Saeed, MD

Role: PRINCIPAL_INVESTIGATOR

MD chest diseases

Locations

Minia University Hospital

Multiple Locations, Minya Governorate, Egypt

Countries

Egypt

Other Identifiers

oxidative stress

Identifier Type: -

Identifier Source: org_study_id