Biomarkers of Early Chronic Obstructive Pulmonary Disease (COPD) in Smokers - Longitudinal Study

NCT ID: NCT02076061

Last Updated: 2022-08-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

300 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-02-28

Study Completion Date

2020-04-30

Brief Summary

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This is a longitudinal observational study to identify and validate protein biomarkers for COPD (chronic obstructive pulmonary diseases) and cardiovascular disease in smokers and ex-smokers attending primary care. Special emphasize is to correlate biomarkers to different phases of COPD, to progression of the disease, and to treatment of the disease. Furthermore, linkage between COPD, cardiovascular disease, and lung cancer will be investigated by identifying protein biomarkers.

Detailed Description

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Conditions

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Chronic Obstructive Pulmonary Disease Cardiovascular Disease Lung Cancer

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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GOLD stage I

No interventions assigned to this group

GOLD Stage II

No interventions assigned to this group

GOLD Stage III

No interventions assigned to this group

GOLD Stage IV

No interventions assigned to this group

Smokers/ex-smokers w/o COPD

No interventions assigned to this group

non-Smokers w/o COPD

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

Diagnosed with COPD Gold stage 0-IV

Exclusion Criteria

Patients with inflammatory diseases Patients with cancer Patients using immune system regulating drugs
Minimum Eligible Age

35 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Örestadskliniken

OTHER

Sponsor Role collaborator

Lund University

OTHER

Sponsor Role lead

Responsible Party

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Johan Malm

Professor, Clincal Chemistry

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Johan Malm

Role: STUDY_CHAIR

Clincal Chemistry, Lund University

György Marko-Varga

Role: PRINCIPAL_INVESTIGATOR

Clinical Protein Science & Imaging, Lund University

Mikael Truedsson

Role: PRINCIPAL_INVESTIGATOR

Örestadskliniken Malmö

Elisabet Wieslander

Role: PRINCIPAL_INVESTIGATOR

Division of Oncology and Pathology, Lund University

Thomas E Fehniger

Role: PRINCIPAL_INVESTIGATOR

Clinical Protein Science & Imaging, Lund University

Magnus Dahlbäck

Role: PRINCIPAL_INVESTIGATOR

Clinical Protein Science & Imaging, Lund University

Roger Appelqvist

Role: PRINCIPAL_INVESTIGATOR

Clinical Protein Science & Imaging, Lund University

Locations

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Örestadskliniken

Malmo, , Sweden

Site Status

Countries

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Sweden

Other Identifiers

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KOL 001

Identifier Type: -

Identifier Source: org_study_id

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