Phenotypes of COPD

NCT ID: NCT03432026

Last Updated: 2018-06-27

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 50 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2019-04-01
• Study Completion Date: 2021-04-01

Brief Summary

Chronic Obstructive Pulmonary Disease (COPD) has been defined by international guidelines as a common preventable and treatable disease characterized by persistent air flow limitation and respiratory symptoms caused by exposure to gases or noxious particles.

COPD is a major cause of morbidity and mortality worldwide. It is predicted to become the third leading cause of death and the fifth leading cause of disability by the year 2020.

Detailed Description

Although the disease has been greatly associated with tobacco smoking, non- smokers can also have COPD, and the burden of COPD in non-smokers is also higher than previously believed especially in developing countries. Exposure to gases, environmental pollution, respiratory infection, noxious particles, passive smoking, and indoor air pollution is the main cause of COPD in non smokers.

COPD over the years has been classified into two phenotypes; chronic bronchitis or classic emphysema.However, The Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines over the last few years have stopped emphasizing the categorization of chronic obstructive pulmonary disease (COPD) into only emphysema or chronic bronchitis

Clear examples of COPD phenotypes in smokers have been described in different Researches,such as emphysema, chronic bronchitis, frequent exacerbators and the asthma_copd overlap.,but there is alack of information about COPD phenotypes in non-smokers, So, there is a continuous need for research into groups of non smoking patients.

Therefore, the aim of this study is to describe the phenotypes of COPD, their risk factors, Clinical and functional assessment and the prognosis of each COPD phenotype in non-smoking patients.

Conditions

Chronic Obstructive Pulmonary Disease

Study Design

• Observational Model Type: CASE_ONLY
• Study Time Perspective: PROSPECTIVE

Study Groups

Non-smoker COPD patients

stable non-smoker COPD patients diagnosed by a previous spiromtery to have FEV1/FVC less than 70

High resolution computed tomography scan of the chest.

Intervention Type: DEVICE

High resolution computed tomography scan of the chest \& pulmonary function tests will be done for every patient to classify them.

Interventions

High resolution computed tomography scan of the chest.

High resolution computed tomography scan of the chest \& pulmonary function tests will be done for every patient to classify them.

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

1. Non-smoker COPD patients.

2. Stable COPD patients (≥4 weeks without exacerbation or worsening of any relevant comorbidity).

Exclusion Criteria

1. Patients with COPD exacerbation.

2. Patients with associated obstructive sleep apnea.

3. Patients with associated interstitial lung disease.

4. patients with associated cardiac problems.

5. Patients with associated bronchiaectasis.

• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Assiut University

OTHER

Sponsor Role: lead

Responsible Party

C F Shamshon

Principal investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

References

Sharma BB, Singh V. Nonsmoker COPD: Is it a reality? Lung India. 2017 Mar-Apr;34(2):117-119. doi: 10.4103/lungindia.lungindia_56_17. No abstract available.

Reference Type: BACKGROUND

PMID: 28360456 (View on PubMed)

Mohan A, Sharma M, Uniyal A, Borah R, Luthra K, Pandey RM, Madan K, Hadda V, Guleria R. Variability in proteinase-antiproteinase balance, nutritional status, and quality of life in stable chronic obstructive pulmonary disease due to tobacco and nontobacco etiology. Lung India. 2016 Nov-Dec;33(6):605-610. doi: 10.4103/0970-2113.192859.

Reference Type: BACKGROUND

PMID: 27890988 (View on PubMed)

Other Identifiers

COPD

Identifier Type: -

Identifier Source: org_study_id