Comparison of Water Sorption Capacity and the Composition of Bronchial Fluids of Healthy Persons and Patients With Chronic Obstructive Bronchitis (COPD)

NCT ID: NCT04703023

Last Updated: 2023-05-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

31 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-07-09

Study Completion Date

2023-05-17

Brief Summary

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Pilot basic research study on the properties of bronchial mucus. Examination of the sorption and desorption properties, mucin concentration, and structure of the mucus from healthy airways compared to patients with Chronic Obstructive Pulmonary Disease (COPD).

Detailed Description

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Mucus, of the correct composition, maintains airway hydration and protects the airway from inhaled particles through mucociliary transport. In chronic inflammatory airway diseases such as COPD or cystic fibrosis, infectious agents, inflammatory cells and products of inflammation such as DNA, increase mucus viscosity which results in decreased mucociliary clearance of inhaled particles, increasing the likelihood of respiratory infections. This pilot study is planned as basic research on the properties of bronchial mucus.

Water isotherms and efficient water activity (sorption and desorption) of the collected samples are examined in defined temperature and humidity settings using DVS Intrinsic (Dynamic Vapour Sorption System, Surface Measurement Systems, London, UK). Findings will provide insights into possible treatment programs targeted at altering specific mucus components.

Conditions

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COPD Healthy

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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COPD

Secretions are collected from Bronchoscopy in clinical routine in COPD patients

No interventions assigned to this group

lung healthy

Secretions are collected from Removal of endotracheal tubes after elective surgery in lung healthy patients

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Age\>18
* COPD or other disease requiring bronchoscopy or elective surgery
* Signed informed consent form

Exclusion Criteria

* Not able to consent
* Linguistic, cognitive, or other obstacles
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Georg Nilius, Prof DR med

INDUSTRY

Sponsor Role lead

Responsible Party

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Georg Nilius, Prof DR med

Clinical Director

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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Kliniken Essen-Mitte, Evang. Huyssens-Stiftung/Knappschaft gGmbH

Essen, North Rhine-Westphalia, Germany

Site Status

Countries

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Germany

Other Identifiers

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MUCUS2020

Identifier Type: -

Identifier Source: org_study_id

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