The Oxidative Stress, Inflammatory Markers, and Metabolomics Response to Exercise in Patients With COPD

NCT ID: NCT04117412

Last Updated: 2023-01-13

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 16 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2019-03-15
• Study Completion Date: 2021-03-15

Brief Summary

The effect of different physical exercise protocols on inflammatory markers, antioxidant balance, and metabolomics has not been fully elucidated. Therefore, the purpose of this study is to investigate the responses of oxidative stress, inflammatory markers, and metabolomics to exercise.

Detailed Description

Chronic obstructive pulmonary disease (COPD), one of the major causes of morbidity and mortality, is a preventable and curable disease characterized by irreversible airflow limitation. The progressive lung involvement, systemic inflammation, respiratory and peripheral muscle dysfunction, loss of muscle mass, and the dysfunction of the remaining muscles occur in COPD. Muscle dysfunction, which is defined as loss of strength or loss of endurance characteristics in muscles, is a comorbidity associated with poor outcomes such as frequent hospitalization and decreased survival, as well as adversely affecting exercise capacity and quality of life. Exercise increases mitochondrial activity and requires antioxidant defense to achieve cellular redox regulation. The effect of different physical exercise protocols on inflammatory markers, antioxidant balance, and metabolomics has not been fully elucidated. Oxidative stress, inflammatory markers, and metabolic responses to different acute exercise modalities in COPD patients need to be examined and clarified. Therefore, the purpose of this study is to investigate the responses of oxidative stress, inflammatory markers, and metabolomics to exercise. Detection of biomolecules that change with acute exercise may also contribute to the identification of exercise-related pathways.

Conditions

Chronic Obstructive Pulmonary Disease

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: NONE

Study Groups

Patients with COPD

Patients with COPD will undergo two different one bout of exercise training after maximal exercise test.

Group Type: OTHER

Exercise

Intervention Type: OTHER

Same participants will undergo different one bout of exercise protocols

Interventions

Exercise

Same participants will undergo different one bout of exercise protocols

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Diagnosis of COPD (clinically stable)
• Being 40-80 years of age
• Able and willing to complete the informed consent process.

Exclusion Criteria

• To have severe neuromuscular, musculoskeletal and rheumatic problems
• Unable to cooperate

• Minimum Eligible Age: 40 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Hacettepe University

OTHER

Sponsor Role: lead

Responsible Party

Aslihan Cakmak

Research Assistant

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Deniz Inal-Ince, PhD

Role: STUDY_DIRECTOR

Hacettepe University

Aslihan Cakmak, MSc

Role: PRINCIPAL_INVESTIGATOR

Hacettepe University

Emirhan Nemutlu, PhD

Role: PRINCIPAL_INVESTIGATOR

Hacettepe University

Samiye Yabanoglu-Ciftci, PhD

Role: PRINCIPAL_INVESTIGATOR

Hacettepe University

Locations

Hacettepe University

Ankara, , Turkey (Türkiye)

Countries

Turkey (Türkiye)

References

Cakmak A, Nemutlu E, Yabanoglu-Ciftci S, Baysal I, Kocaaga E, Coplu L, Inal-Ince D. Metabolomic, oxidative, and inflammatory responses to acute exercise in chronic obstructive pulmonary disease. Heart Lung. 2023 May-Jun;59:52-60. doi: 10.1016/j.hrtlng.2023.01.011. Epub 2023 Jan 30.

Reference Type: DERIVED

PMID: 36724589 (View on PubMed)

Other Identifiers

GO 18/1121-05

Identifier Type: -

Identifier Source: org_study_id