Mechanistic Studies of Chronic COPD Using Single-Cell Sequencing and Single-Cell Spatial Transcriptomics

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

150 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-09-30

Study Completion Date

2027-12-31

Brief Summary

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This study is an ambispective cohort study, the sample from patients were from both previously stored and freshly collected . The objective of this study is to investigate the molecular pathological changes underlying the development of chronic obstructive pulmonary disease (COPD). We will use single cell sequencing technology to analyze lung tissue samples from patients who underwent lung resection, with lung tissue from patients without COPD serving as controls. This research aims to provide insights into the pathogenesis of COPD.

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Detailed Description

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Conditions

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COPD

Study Design

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Observational Model Type

OTHER

Study Time Perspective

OTHER

Study Groups

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COPD group

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Receiving lung resection surgery at the hospital for any reason；
* Diagnosed with COPD according to the 2024 GOLD guidelines；
* Tissue samples that meet collection requirements and are either agreed to be collected or already preserved；

Exclusion Criteria

* Improper preservation of pathological specimens, refusal to consent to sample collection, or incomplete clinical information；
* Combined with other factors causing obstructive airflow limitation;
* Diagnosed with asthma according to the GINA 2023 guidelines and with a history of asthma exacerbations within the past year;
* Combined with Advanced lung cancer;
* Receiving systemic immunosuppressive medications such as anti-rejection drugs;

Eligible Sex

ALL

Accepts Healthy Volunteers

No