CARTO-Finder Guided Ablation Versus Multiscale Entropy Guided Ablation in Persistent Atrial Fibrillation
NCT ID: NCT05454111
Last Updated: 2022-07-12
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
NA
200 participants
INTERVENTIONAL
2022-09-01
2025-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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CARTO-Finder-guided ablation plus PVI
Pulmonary vein circumferential isolation + + ablation of sites recognized by CARTO-Finder module as the core of rotors.
CARTO-Finder-guided ablation plus PVI
CARTO-Finder-guided ablation plus PVI
Multiscale entropy-guided ablation plus PVI
Pulmonary vein circumferential isolation + ablation of sites recognized by multiscale entropy analysis as the core of rotors.
Multiscale entropy-guided ablation plus PVI
The multiscale entropy is calculated based on intracardiac electrical signals, higher multiscale entropy value indicates closer to the core of rotors which maintains the persistent atrial fibrillation.
Interventions
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Multiscale entropy-guided ablation plus PVI
The multiscale entropy is calculated based on intracardiac electrical signals, higher multiscale entropy value indicates closer to the core of rotors which maintains the persistent atrial fibrillation.
CARTO-Finder-guided ablation plus PVI
CARTO-Finder-guided ablation plus PVI
Eligibility Criteria
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Inclusion Criteria
2. Persistent AF
3. Nonresponse or intolerance to ≥1 antiarrhythmic drug
Exclusion Criteria
2. Having significant valvular disease;
3. Having moderate-to-severe pulmonary hypertension;
4. With myocardial infarction or stroke within 6 months of screening;
5. With Significant congenital heart disease;
6. Ejection fraction was \<40% measured by echocardiography;
7. Allergic to contrast media;
8. Contraindication to anticoagulation medications;
9. Severe pulmonary disease e.g. restrictive pulmonary disease, chronic obstructive disease (COPD);
10. Left atrial thrombus;
11. Having any contraindication to right or left sided heart catheterization
18 Years
80 Years
ALL
No
Sponsors
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Shandong University of Traditional Chinese Medicine
OTHER
Department of Cardiology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine
UNKNOWN
Wuhan Central Hospital
OTHER
Department of Cardiology, Affiliated Hospital of Jining Medical University
UNKNOWN
Department of Cardiology, Yuhuan Second People's Hospital
UNKNOWN
Department of Cardiology, Changshu Hospital of Traditional Chinese Medicine
UNKNOWN
Department of Cardiology, The PLA Navy Anqing Hospital
UNKNOWN
Department of Cardiology, Jinan City People's Hospital
UNKNOWN
Department of Cardiology, Xuzhou Central Hospital
UNKNOWN
Shanghai Chest Hospital
OTHER
Responsible Party
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Xu Liu
Professor, deputy director of cardiology department of Shanghai Chest Hospital
Locations
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Shanghai Chest Hospital
Shanghai, , China
Countries
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Central Contacts
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Facility Contacts
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Xu Liu, Dr.
Role: primary
Other Identifiers
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Find-AF
Identifier Type: -
Identifier Source: org_study_id
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