Elasticity of the Hoffa's Fat Pad in Patients With Knee Osteoarthritis

NCT ID: NCT05439317

Last Updated: 2023-02-22

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 33 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2021-12-03
• Study Completion Date: 2022-08-05

Brief Summary

Knee osteoarthritis (OA) is a common problem in clinical settings. Knee OA is well known for its association with the wear and tear of the cartilage and osteophyte formation. Evidence has suggested the importance of the infrapatellar fat pad, known as Hoffa's fat pad, during the development of knee OA. Some studies have demonstrated the protective role of the infrapatellar fat pad, whereas others have suggested an inflammatory role such as increased fibrosis and proinflammatory cytokine levels. Ultrasound is exceptionally convenient in the assessment of the musculoskeletal system, and elastography is a tool to evaluate tissue texture. Therefore, in this study, we investigated the Hoffa's fat pad in knee OA patients by using elastography.

Detailed Description

This was an observation study that included a control group. We enrolled 20 patients with knee OA, as well as 10 healthy individuals. The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Kellgren-Lawrence X-ray grading were employed to determine disease severity. All the study participants received elastography assessment, including strain and shear wave elastography in the knee extension and flexion position. The strain elastography contained color mapping that enabled the calculation of the relative texture and strain ratio. The shear wave elastography revealed the qualitative velocity, which was measured 3 times. Each patients with knee OA received elastography examination twice: once before hyaluronic acid injection and once 1 month after the injection.

Conditions

Knee Osteoarthritis; Elasticity Imaging Techniques

Study Design

• Observational Model Type: OTHER
• Study Time Perspective: PROSPECTIVE

Study Groups

knee osteoarthritis group

individuals being diagnosed with osteoarthritis and classified by K-L grading

No interventions assigned to this group

healthy group

individuals without knee pain or diagnosis of knee osteoarthritis

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

OA group

• Kellgren-Lawrence grading I-IV proved by knee X-ray Healthy group
• No knee pain or received injection during the past 1 year
• No history of knee OA

Exclusion Criteria

• History of knee surgery, trauma or malignancy
• History of patellar tendinopathy or patellofemoral pain syndrome
• Refused informed consent

• Minimum Eligible Age: 20 Years
• Maximum Eligible Age: 86 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Taipei Veterans General Hospital, Taiwan

OTHER_GOV

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Ding-Hao Liu

Role: STUDY_CHAIR

Physical and Rehabilitation Medicine, Veterans General Hospital

Locations

Taipei Veterans General Hospital

Taipei, , Taiwan

Countries

Taiwan

Other Identifiers

2021-09-013AC

Identifier Type: -

Identifier Source: org_study_id