Non-invasive Left Ventricle Contractility dp/dt as Prognostic Marker in Chest Unit Patients

NCT ID: NCT05416112

Last Updated: 2023-05-16

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 500 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2022-06-01
• Study Completion Date: 2023-09-30

Brief Summary

Ischemic heart disease is a major public health problem with high mortality rate despite the progress in management and the resources mobilized. The idea is that myocardial ischemia is generally associated with left ventricular dysfunction and, consequently, a possible alteration of the dp/dt index. As dp/dt could be assessed non-invasively by plethysmographic method, it is interesting to investigate its prognostic performance in patients with indifferentiate chest pain.

Detailed Description

Ischemic heart disease remains a major public health problem. Despite all the advances in the prognostic approach to ischemic heart disease, the risk of occurrence of major cardiovascular events is not negligible. Several scores have been proposed for chest pain stratification risk, the most widely used are the TIMI and the GRACE scores.

The dP/dt max is therefore an excellent index of contractility, corresponding to the maximum level of tension developed by an isolated cardiac muscle during the isovolumic contraction phase.

the investigator theorized that a less value of dp/dt would be associated with more major cardiovascular events (MACE), because ischemia reduces myocardial contractility.

The current study describes non-invasive plethysmographic dp/dt changes, which could be used as a prognostic marker in patients presenting at the emergency department with acute chest pain.

Conditions

Chest Pain

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Eligibility Criteria

Inclusion Criteria

• age over 18 years old,
• acute chest pain

Exclusion Criteria

• traumatic chest pain,
• hemodynamic instability;
• arrhythmias;
• holders of a pacemaker;
• STEMI

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

University of Monastir

OTHER

Sponsor Role: lead

Responsible Party

Pr. Semir Nouira

PROFESSOR

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Nouira Semir, professor

Role: PRINCIPAL_INVESTIGATOR

Monastir University Hospital, Monastir, Tunisia, 5000

Locations

Emergency Departement

Monastir, , Tunisia

Site Status: RECRUITING

Countries

Tunisia

Central Contacts

Nouira Semir, professor

Role: CONTACT

semir.nouira@rns.tn

73106046 ext. 00216

Facility Contacts

Semir Nouira, professor

Role: primary

semir.nouira@rns.tn

73 106 085 ext. 216

Other Identifiers

dp/dt

Identifier Type: -

Identifier Source: org_study_id