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Chronic and Acute Effects of Smoking on the Left and Right Ventricular Relaxation in Young Healthy Smokers

NCT ID: NCT00395928

Last Updated: 2006-11-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

33 participants

Study Classification

OBSERVATIONAL

Study Start Date

2001-11-30

Study Completion Date

2004-11-30

Brief Summary

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Impairment of relaxation, the early phase of ventricular diastole is the first stage of heart diastolic dysfunction. Left ventricular diastolic function can be determined noninvasively by Echo- Doppler - derived mitral valve flow velocities. The addition of pulmonary venous flow pattern enables more accurate assessment of left ventricle diastolic function. The role of the right ventricle in haemodynamic function of the heart is now emphasized. The right ventricle diastolic function can be assess by recording the Doppler tricuspid valve flow pattern. Impaired LV diastolic function usually precedes systolic dysfunction and may cause clinical signs of congestive heart failure. Cigarette smoking is one of the major risk factors for cardiovascular diseases. The aim of the study was to assess left and right ventricular diastolic function in healthy, young and slim smokers before and after smoking one cigarette.

Echocardiographic examination: before and after smoking one cigarette Echocardiographic evaluation of mitral valve flow, pulmonary venous flow, tricuspid valve flow and hepatic vein flow to assess diastolic function of ventricles.

Detailed Description

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Echocardiographic examination: in left lateral position after 10 minutes rest. The first examination: after a 2-hour non-smoking period, the second: immediately after smoking one cigarette containing 0.9 mg of nicotine. The duration of the second examination: no more than 15 minutes.

Echocardiography equipment: Hewlett-Packard SONOS 2000 (Andover, Massachusetts) imaging system. The transducer's frequency: 2 MHz.

From the apical four chamber view the visualisation of transmitral flow, pulmonary venous flow and transtricuspid flow. From subcostal view the visualisation of right superior hepatic vein and the hepatic vein flow.

Conditions

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Cardiovascular Diseases

Keywords

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heart echocardiography diastolic function left ventricle right ventricle cigarette smoking Smoking Heart Ventricles Diastole Doppler Echocardiography

Study Design

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Observational Model Type

DEFINED_POPULATION

Study Time Perspective

OTHER

Eligibility Criteria

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Inclusion Criteria

* Smokers smoking over 10 cigarettes per day over the last 5 years
* Body mass index \< 25 kg/m2
* Normal blood pressure and normal parameters of echocardiographic examination (wall thickness, left- and right- chamber size, valvular function and left and right ventricular systolic function)
* Normal results of routine physical examination, chest x-ray, standard rest electrocardiogram and routine laboratory tests.

Exclusion Criteria

* Body mass index \> 25 kg/m2
* Abnormal blood pressure
* Abnormal parameters of echocardiographic examination (wall thickness, left- and right- chamber size, valvular function and left and right ventricular systolic function)
* Abnormal results of routine physical examination, chest x-ray, standard rest electrocardiogram and routine laboratory tests.
Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Medical University of Warsaw

OTHER

Sponsor Role lead

Principal Investigators

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Danuta Liszewska-Pfejfer, Prof.

Role: STUDY_CHAIR

Internal Medicine and Cardiology Dpt, Warsaw Medical University

Locations

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Internal Medicine and Cardiology Dpt,Institute of Dentistry,Warsaw Medical University

Warsaw, Lindleya 4, Poland

Site Status

Countries

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Poland

References

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Oh JK, Appleton CP, Hatle LK, Nishimura RA, Seward JB, Tajik AJ. The noninvasive assessment of left ventricular diastolic function with two-dimensional and Doppler echocardiography. J Am Soc Echocardiogr. 1997 Apr;10(3):246-70. doi: 10.1016/s0894-7317(97)70062-2.

Reference Type BACKGROUND
PMID: 9109691 (View on PubMed)

Klein AL, Tajik AJ. Doppler assessment of pulmonary venous flow in healthy subjects and in patients with heart disease. J Am Soc Echocardiogr. 1991 Jul-Aug;4(4):379-92. doi: 10.1016/s0894-7317(14)80448-3.

Reference Type BACKGROUND
PMID: 1910836 (View on PubMed)

Voutilainen S, Kupari M, Hippelainen M, Karppinen K, Ventila M, Heikkila J. Factors influencing Doppler indexes of left ventricular filling in healthy persons. Am J Cardiol. 1991 Sep 1;68(6):653-9. doi: 10.1016/0002-9149(91)90360-w.

Reference Type BACKGROUND
PMID: 1877483 (View on PubMed)

Alam M, Samad BA, Wardell J, Andersson E, Hoglund C, Nordlander R. Acute effects of smoking on diastolic function in healthy participants: studies by conventional doppler echocardiography and doppler tissue imaging. J Am Soc Echocardiogr. 2002 Oct;15(10 Pt 2):1232-7. doi: 10.1067/mje.2002.124006.

Reference Type BACKGROUND
PMID: 12411910 (View on PubMed)

Other Identifiers

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KB/126/2001

Identifier Type: -

Identifier Source: org_study_id