Myocarditis Causing Premature Ventricular Contractions:Insights From the MAVERIC Registry
NCT ID: NCT05158751
Last Updated: 2025-09-04
Study Results
Results pending
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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Recruitment Status
NOT_YET_RECRUITING
Total Enrollment
100 participants
Study Classification
OBSERVATIONAL
Study Start Date
2026-01-31
Study Completion Date
2026-05-31
Brief Summary
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To assess potential link between unrecognized myocardial inflammation (myocarditis) and premature ventricular contractions (PVCs) associated with and without reduced Left ventricular ejection fraction (LVEF) through comprehensive diagnostic work up.
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Detailed Description
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Hypothesized that occult inflammation is clinically under-recognized in patients with symptomatic PVCs with and without Left ventricular (LV) dysfunction and can be a potential link between the 2 conditions. Aimed to evaluate the incidence of underlying inflammation using the Positron emission tomography (PET) scan in patients presenting with symptomatic PVCs enrolled retrospectively in the MAVERIC registry.
Conditions
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Myocarditis
Premature Ventricular Contractions
Ventricular Tachycardia (VT)
Study Design
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Observational Model Type
COHORT
Study Time Perspective
RETROSPECTIVE
Eligibility Criteria
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Inclusion Criteria
* Patients \> 18 years of age with mono-morphic or polymorphic PVC burden of ≥5000 in 24 hours.
* Non-sustained VT was defined as ≥3 more consecutive beats lasting \<30 seconds
* Non-sustained VT was defined as ≥3 more consecutive beats lasting \<30 seconds
Exclusion Criteria
* History of myocardial infarction,
* Significant flow-limiting coronary artery disease (≥50% stenosis) on invasive coronary angiography or CT angiography,
* History of revascularization,
* Significant symptomatic atrial arrhythmias associated with LV dysfunction,
* Severe valvular disease,
* Cardiomyopathy attributed to toxins such as alcohol and illicit drugs,
* History of cardiac arrest,
* History of channelopathies or inherited arrhythmias.
* Significant flow-limiting coronary artery disease (≥50% stenosis) on invasive coronary angiography or CT angiography,
* History of revascularization,
* Significant symptomatic atrial arrhythmias associated with LV dysfunction,
* Severe valvular disease,
* Cardiomyopathy attributed to toxins such as alcohol and illicit drugs,
* History of cardiac arrest,
* History of channelopathies or inherited arrhythmias.
Minimum Eligible Age
18 Years
Eligible Sex
ALL
Accepts Healthy Volunteers
No
Sponsors
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Kansas City Heart Rhythm Institute
OTHER
Sponsor Role
collaborator
Kansas City Heart Rhythm Research Foundation
OTHER
Sponsor Role
lead
Responsible Party
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Responsibility Role
SPONSOR
Principal Investigators
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Dhanunjaya Lakkireddy, MD
Role: PRINCIPAL_INVESTIGATOR
Kansas City Heart Rhythm Institute
Locations
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Kansas City Heart Rhythm Institute
Overland Park, Kansas, United States
Site Status
Countries
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United States
Central Contacts
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Facility Contacts
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References
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Other Identifiers
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KCHRF-MAVERIC REG-0009
Identifier Type: -
Identifier Source: org_study_id
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