The Incidence of Postoperative Pulmonary Complications in Patients With a Positive and Negative AIR-Test During General Anesthesia

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

632 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-04-21

Study Completion Date

2024-06-01

Brief Summary

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The overall objective of this study is to describe the incidence of postoperative pulmonary complications in patients with a positive and negative AIR-test result. Second, the investigators wish to describe the incidence of a positive AIR-test and its association with the development of PPC. In addition, the investigators aim to describe whether mechanical ventilation strategy differs between patients with a positive and negative AIR-test.

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Detailed Description

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The 'AIR-test', a method wherein inspiratory oxygen concentration is reduced to 21% and pulse-oximetry hemoglobin saturation (SpO2) is monitored, can be used to demonstrate the presence of an atelectasis-induced alveolar shunt. It remains uncertain whether an intraoperative positive AIR-test is associated with clinical outcomes. It is hypothesized that in a general surgical population, the incidence of postoperative pulmonary complications (PPC) is higher in patients with a positive AIR-test than in patients with a negative AIR-test. The aim of this study is to describe the incidence of PPC in patients with a positive and in patients with a negative AIR-test. Second, the investigators want to describe the incidence of a positive AIR-test and its association with the development of PPC. The investigators also want to evaluate whether mechanical ventilation strategy differs between patients with a positive and negative AIR-test.

Conditions

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Surgery--Complications Atelectasis Anesthesia

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Positive AIR-test

Patients with a positive intraoperative AIR-test result

Surgery

Intervention Type PROCEDURE

All types of surgery requiring general anesthesia

Negative AIR-test

Patients with a negative intraoperative AIR-test result

Surgery

Intervention Type PROCEDURE

All types of surgery requiring general anesthesia

Interventions

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Surgery

All types of surgery requiring general anesthesia

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Patients undergoing surgery under general anesthesia in the Amsterdam University Medical Centers, location Meibergdreef with an Endotracheal Tube;
* Patients \> 18 years;
* Preoperative SpO2 of ≥97%;
* AIR-test performed after induction of anesthesia, in a hemodynamic and respiratory steady state.

Exclusion Criteria

* Age \< 18 years;
* No consent/objection;
* Patient participated in another conflicting interventional study on mechanical ventilation during general anesthesia

Minimum Eligible Age

18 Years

Maximum Eligible Age

110 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No