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Arterial and End-Tidal CO2 Gradient as a Mortality Predictor in Critical Care Patients

NCT ID: NCT05341258

Last Updated: 2022-08-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

50 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-01-01

Study Completion Date

2022-08-01

Brief Summary

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Scoring systems (SOFA, APACHE-II etc.) are used to estimate the mortality rates of patients treated in the intensive care unit. . In the scoring systems used, the disfunction level of the organs of the patients is measured. Blood gas analysis is routinely performed in patients whom intubated in the intensive care unit and receiving mechanical ventilation support, and the patient's treatment is optimized according to the results of the examination. The patient's mechanical ventilation settings are regulated by analyzing the Partial Arterial Carbondioxide (paCO2) value in the patient's blood gas result. The difference between the paCO2 value in the blood gas and the End-tidal Carbondioxide (EtCO2) value measured in the mechanical ventilator is 3-5mmHg in normal healthy people, while this difference is seen more in critical care patients. In critically ill patients in the intensive care unit, there is a greater increase in the difference between paCO2 and ETCO2 in cases where mortality is high, such as global perfusion disorder, shock situations, and massive pulmonary embolism, etc. In this study, it was planned to investigate the use of the difference between the paCO2 value in the blood gas taken from the patient and the ETCO2 value measured in the mechanical ventilator to predict the mortality rate of the patient.

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Detailed Description

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Conditions

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Critical Illness Ventilation Perfusion Mismatch Shock Pulmonary Embolism Trauma Copd

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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Critical Care Patients whom intubated last 24 hours

Critical Care Patients whom intubated last 24 hours

Group Type OTHER

EtCO2

Intervention Type DIAGNOSTIC_TEST

EtCO2

PaCO2

Intervention Type DIAGNOSTIC_TEST

PaCO2

Interventions

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EtCO2

EtCO2

Intervention Type DIAGNOSTIC_TEST

PaCO2

PaCO2

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Critical Care Patients intubated in last 24 hours.

Exclusion Criteria

* Patients younger than 18 years old.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Gaziosmanpasa Research and Education Hospital

OTHER_GOV

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Ulku Aygen Turkmen, Proffessor

Role: STUDY_DIRECTOR

Director of Anesthesiology and Reanimation Department

Locations

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Gaziosmanpasa Training Research Hospital

Istanbul, , Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

Other Identifiers

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3751

Identifier Type: -

Identifier Source: org_study_id

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