Brain Activity in Epilepsy

NCT ID: NCT05307146

Last Updated: 2022-04-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-12-18

Study Completion Date

2035-01-01

Brief Summary

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Prospective interventional study with implantation of micro-electrodes to study the brain networks in epilepsy at high spatiotemporal resolution.

Detailed Description

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The goal of this trial is to study brain activity in epilepsy at high spatiotemporal resolution. Apart from the epileptogenic network (dysfunctional areas), the investigators will study human brain function.

The use of micro-electrode arrays allows to study the human brain a high spatiotemporal resolution, even at the single neuron level.

Scientific objectives of the current project:

* To record neural signals from macro-electrodes and delineate the epileptogenic network and study brain function during specific tasks.
* To record neural signals from micro-electrodes and delineate the epileptogenic network and study brain function during specific tasks.
* Identifying pivotal regions for BMI applications and developing online decoding algorithms.
* Comparing neural recordings to fMRI activity

Conditions

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Epilepsy

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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micro/macro electrode

Group Type EXPERIMENTAL

macro/micro electrode recording

Intervention Type DEVICE

intracranial macro/micro-electrode placement at the cerebral cortex or in deeper brain areas with te use of macro/micro electrode recording. Macro/micro electrodes are placed at the cerebral cortex or in deeper brain areas in order to precisely identify the epileptogenic focus

Interventions

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macro/micro electrode recording

intracranial macro/micro-electrode placement at the cerebral cortex or in deeper brain areas with te use of macro/micro electrode recording. Macro/micro electrodes are placed at the cerebral cortex or in deeper brain areas in order to precisely identify the epileptogenic focus

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Age ≥18 yo
* Epilepsy patients undergoing intracranial electrode placement.
* Able to understand the procedure involved and to consent.

Exclusion Criteria

* Age \< 18 yo
* Pregnancy
Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Universitaire Ziekenhuizen KU Leuven

OTHER

Sponsor Role lead

Responsible Party

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Tom Theys

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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UZ Leuven

Leuven, , Belgium

Site Status RECRUITING

Countries

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Belgium

Central Contacts

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Anaïs Van Hoylandt

Role: CONTACT

Facility Contacts

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Anaïs Van Hoylandt

Role: primary

Other Identifiers

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S53126

Identifier Type: -

Identifier Source: org_study_id

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