Study on Neurocognitive Plasticity in Patients With Focal and Drug-resistant Epilepsy

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

37 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-10-21

Study Completion Date

2022-07-05

Brief Summary

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This study consist of define anatomo-functional reorganization (plasticity) profiles for the mentioned cognitive functions, before surgery (chronic plasticity induced by the epileptogenic zone) in patients with drug-resistant epilepsy.

For that, patients will have 2 MRI examinations, one before surgery and the second, between 3 and 8 months after surgery.

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Detailed Description

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Conditions

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Epilepsy

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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epileptic Patients

Group Type EXPERIMENTAL

MRI exam

Intervention Type OTHER

MRI before and after resection surgery

Interventions

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MRI exam

MRI before and after resection surgery

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patients with diagnosis of pharmaco-resistant focal epilepsy
* Patient candidate for surgery to resect the epileptogenic zone
* Patients affiliated to a social security scheme or beneficiaries of such a scheme
* Patients with French as their mother tongue
* Patients who have given signed informed consent before performing any procedure related to the study.

Exclusion Criteria

* Contraindication to performing an MRI:
* Intellectual disability objectified by a Mini Mental Score (MMS) score \<24 in the year preceding inclusion,
* Existence of a severe condition in general: cardiac, respiratory, hematological, renal, hepatic, cancerous,
* Participation in other research protocols underway with exclusion period or in the previous week,
* Persons referred to in Articles L1121-5 to L1121-8 of the Public Health Code.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No