Human Single Neuron Recordings in Epilepsy Patients

NCT ID: NCT04290416

Last Updated: 2020-02-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-02-04

Study Completion Date

2021-12-31

Brief Summary

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This study uses single neuron recordings in pre-surgical epilepsy patients to uncover the neural mechanisms underlying memory formation and retrieval. A secondary aim is to improve diagnostic tools to identify epileptogenic tissue.

Detailed Description

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Conditions

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Epilepsy Memory

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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Microwire electrodes

Activity of individual neurons will be recorded via microwire contacts. These microwire electrodes do not interfere with the macrowire clinical recordings.

Group Type EXPERIMENTAL

Microwire electrodes

Intervention Type DIAGNOSTIC_TEST

Interventions

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Microwire electrodes

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Interest in participation.
* Temporal lobe epilepsy that is clinically being investigated with implantations of depth electrodes as part of the pre-surgical epilepsy monitoring.
* Cognitive/language skills sufficient to follow experimental instruction and maintain focus on the experiment.

Exclusion Criteria

* Patient does not want to participate.
* Extra-temporal epilepsy, or electrode implantation strategy that does not allow the use of micro-macrowire electrodes.
* Cognitive/language skills insufficient to follow experimental instruction and maintain focus on the experiment.
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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European Commission

OTHER

Sponsor Role collaborator

Queen Elizabeth Hospital NHS Foundation Trust

OTHER

Sponsor Role collaborator

University of Birmingham

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Simon Hanslmayr, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Birmingham

Locations

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Queen Elizabeth UHB Hospital

Birmingham, West Midlands, United Kingdom

Site Status

Countries

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United Kingdom

Other Identifiers

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RG_15-074

Identifier Type: -

Identifier Source: org_study_id