Study of the Effects of a New Infant Formula Supplemented With a Probiotic Over the Corporal Composition of Infants

NCT ID: NCT05303077

Last Updated: 2022-04-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

210 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-02-11

Study Completion Date

2020-11-25

Brief Summary

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This is a multicentric, randomized, blinded, controlled trial to study the effects of a new infant formula on the changes in the newborn body composition over time: weight gain, anthropometric data, incidence of infections, digestive tolerance (flatulence, vomiting and regurgitation), feces (consistency and frequency), behavior (restlessness, colic, nocturnal awakenings), count of probiotic strains of the intestinal microbiota in feces, safety and tolerability of the investigational products (measured as number, frequency and severity of adverse events in all branches of the study)

Detailed Description

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Conditions

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Healthy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

DOUBLE

Participants Investigators
The 2 infant formula arms are blinded for the participant, investigator and data analyst. The 3rd arm is an open control group conformed by breastfeed infants

Study Groups

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Study Infant Formula

Infant formula supplemented with omega 3 fatty acids and inactive Bifidobacteria

Group Type EXPERIMENTAL

Nutribén Innova® 1

Intervention Type DIETARY_SUPPLEMENT

Infants are fed solely with infant formula supplemented with an inactive probiotic and omega 3 fatty acids over the first 6 months of their life, from then on the infants are fed with the study formula and the usual supplementary food, recommended to the baby's

Infant Formula

Infant formula

Group Type ACTIVE_COMPARATOR

Nutribén®

Intervention Type DIETARY_SUPPLEMENT

Infants are fed solely with infant formula over the first 6 months of their life, from then on the infants are fed with the study formula and the usual supplementary food, recommended to the baby's age.

Breastfeed Active comparator

Infants who are breastfed

Group Type ACTIVE_COMPARATOR

Breastfeed

Intervention Type DIETARY_SUPPLEMENT

Infants are breastfeeding solely over the first 6 months of their life, from then on the infants are fed as recommended by their caregiver, as if they are not participating in a research study.

Interventions

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Nutribén Innova® 1

Infants are fed solely with infant formula supplemented with an inactive probiotic and omega 3 fatty acids over the first 6 months of their life, from then on the infants are fed with the study formula and the usual supplementary food, recommended to the baby's

Intervention Type DIETARY_SUPPLEMENT

Nutribén®

Infants are fed solely with infant formula over the first 6 months of their life, from then on the infants are fed with the study formula and the usual supplementary food, recommended to the baby's age.

Intervention Type DIETARY_SUPPLEMENT

Breastfeed

Infants are breastfeeding solely over the first 6 months of their life, from then on the infants are fed as recommended by their caregiver, as if they are not participating in a research study.

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* Healthy children. Both sex.
* Full term infants (between 37 and 42 weeks of pregnancy).
* Birth weight between 2500 g- 4500 g.
* Single birth babies.
* BMI of the mothers before the pregnancy between 19 y 30 kg/m2.

Exclusion Criteria

* Body weight lower than the 5th percentile for their gestational age.
* Cow's milk protein allergy and/or lactose allergy.
* Administration of antibiotics 7 days prior inclusion.
* Congenital disease or malformation that may affect the infant growth rate.

Population Description: The study population are newborns selected from primary care clinics in Spain.

Sampling Method: Not applicable

* Metabolic disease or disorders.
* Significant prenatal disease and/or serious postnatal disease before recruitment.
* Underage parents.
* Diabetic mother.
* Born from a drug abuse mother (who use abuse drugs during pregnancy).
* Parents cannot comply with study procedures.
* Subject included or that have been included in other clinical trial since his/her birth day.
Minimum Eligible Age

15 Days

Maximum Eligible Age

25 Days

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Fundación Teófilo Hernando, Spain

OTHER

Sponsor Role collaborator

Biopolis S.L.

INDUSTRY

Sponsor Role collaborator

Alter Farmacia, S.A.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Cap Montclar

Barcelona, , Spain

Site Status

Cap Nova Lloreda

Barcelona, , Spain

Site Status

Cap Sant Ildefons

Barcelona, , Spain

Site Status

Consulta Dr. Xavier Riopedre

Barcelona, , Spain

Site Status

Consulta Carlos Nuñez de Prado Aparicio

Madrid, , Spain

Site Status

Consultorio Arroyomolinos (Cs Parque Coimbra)

Madrid, , Spain

Site Status

Cs Alcalde Bartolomé Gonzalez Móstoles

Madrid, , Spain

Site Status

Cs Conde de Barcelona

Madrid, , Spain

Site Status

Cs Dr Luengo Rodríguez

Madrid, , Spain

Site Status

Cs Infante Don Luis de Borbón

Madrid, , Spain

Site Status

Cs La Rivota

Madrid, , Spain

Site Status

Cs Las Américas

Madrid, , Spain

Site Status

Cs Miguel Servet

Madrid, , Spain

Site Status

Cs Parque Loranca

Madrid, , Spain

Site Status

Cs Presentación Sabio

Madrid, , Spain

Site Status

Cs Valle de La Oliva

Madrid, , Spain

Site Status

Clínica Dr Aguilar-Dr Sacristán

Seville, , Spain

Site Status

Consultas Externas Hospital Privado Santa Ángela de La Cruz

Seville, , Spain

Site Status

Cs Amante Laffón

Seville, , Spain

Site Status

Cs Utrera Norte

Seville, , Spain

Site Status

Ihp Bellavista

Seville, , Spain

Site Status

Countries

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Spain

Other Identifiers

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INNOVA 2020

Identifier Type: -

Identifier Source: org_study_id

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