Ergogenic Properties of Magnesium Supplementation

NCT ID: NCT05282693

Last Updated: 2024-05-16

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 41 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2021-12-17
• Study Completion Date: 2024-02-28

Brief Summary

The purpose of the proposed project is to determine if short-term dietary supplementation of magnesium will improve performance during a series of lab-based exercise tests, will favorably modify the gut-microbiota, and will augment skeletal muscle mitochondrial function.

Detailed Description

Magnesium is the fourth most abundant mineral in the human body. It is critical to day-to-day physiological function including the regulation of metabolism, cardiovascular function, immune function, and the operation of the nervous system. In light of its important role in physiology, dietary supplementation of magnesium has been purported to improve athletic performance, although the precise mechanism is unclear. The foci of the proposed study is the ergogenic effects of magnesium, its potential influence on gut health, and its potential ability to improve skeletal muscle function. The investigators will be studying an athletic/competitive population of endurance-trained adults. This group is likely to be the most interested in the use of magnesium to enhance athletic performance. Also, by only recruiting habitual exercisers, the variability between participants is likely to be reduced compared with if the investigators had also recruited people who are usually sedentary.

Conditions

Exercise Performance; Gut -Microbiota; Mitochondrial Function

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: TRIPLE

Study Groups

ReMag

Liquid Lemon flavor drink containing 300 mg magnesium chloride (Regmag) consumed twice daily for 9 days

Group Type: EXPERIMENTAL

ReMag

Intervention Type: DIETARY_SUPPLEMENT

300 mg of ReMag dissolved in lemon flavor liquid

ReMag Placebo

Liquid Lemon flavor drink placebo comparator consumed twice daily for 9 days.

Group Type: PLACEBO_COMPARATOR

Placebo

Intervention Type: DIETARY_SUPPLEMENT

Lemon flavored liquid

Interventions

ReMag

300 mg of ReMag dissolved in lemon flavor liquid

Intervention Type: DIETARY_SUPPLEMENT

Placebo

Lemon flavored liquid

Intervention Type: DIETARY_SUPPLEMENT

Other Intervention Names

Magnesium Chloride

Eligibility Criteria

Inclusion Criteria

• Competitive cyclists
• Adult males and females (18 - 40 years, inclusive) who have exercised a minimum of 5 days per week, for a minimum of 30-minutes/session, during the previous 2 years.
• Maximal oxygen uptake (VO2max) satisfying the minimum criteria for "Good" (sex- and age-adjusted) as defined by the American College of Sports Medicine.

Exclusion Criteria

• Identification of a contra-indication to exercise during a 12-lead exercise stress test
• Use of a magnesium supplement within the previous 4 weeks
• Pregnancy or breast-feeding
• Unable to perform vigorous exercise
• History (previous diagnosis) of kidney disease
• Use of laxatives, Zinc, diuretics, proton pump inhibitors, over the counter agents such as certain heartburn and GI/gut treatments (laxatives) which contain magnesium, Zinc or other high dose cations which reduce absorption of Magnesium

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 40 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Christopher Bell

OTHER

Sponsor Role: lead

Responsible Party

Christopher Bell

Associate Professor

Responsibility Role: SPONSOR_INVESTIGATOR

Locations

Colorado State University, Dept. of Health and Exercise Science

Fort Collins, Colorado, United States

Countries

United States

Other Identifiers

1659

Identifier Type: -

Identifier Source: org_study_id