Effectiveness of Food-grown Magnesium on Sleep Quality/Quantity

NCT ID: NCT05825209

Last Updated: 2023-10-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

84 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-04-06

Study Completion Date

2023-07-04

Brief Summary

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This is a double-blind randomised placebo-controlled trial to evaluate orally-dosed food-grown magnesium compared to placebo on improvement in sleep quality and quantity as well as quality of life in otherwise healthy participants aged 18 years and older.

Detailed Description

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Conditions

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Sleep

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Food-Grown Magnesium

Food-grown magnesium in capsule form - taken as 2 capsules, orally with water 1 hour before sleep.

Group Type ACTIVE_COMPARATOR

Food-Grown Magnesium

Intervention Type DRUG

1 daily dose of 2 capsules equivalent to 80mg food-grown magnesium (40mg per capsule)

Microcrystalline cellulose

Microcrystalline cellulose in capsule form - taken as 2 capsules, orally with water 1 hour before sleep.

Group Type PLACEBO_COMPARATOR

Microcrystalline cellulose

Intervention Type DRUG

1 daily dose of 2 capsules containing microcrystalline cellulose

Interventions

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Food-Grown Magnesium

1 daily dose of 2 capsules equivalent to 80mg food-grown magnesium (40mg per capsule)

Intervention Type DRUG

Microcrystalline cellulose

1 daily dose of 2 capsules containing microcrystalline cellulose

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Adults 18 years or older
* Otherwise healthy
* Disturbed sleeping pattern (defined as difficulty falling asleep, waking up during the sleep cycle or waking up too early and being unable to fall back to sleep)
* Able to provide informed consent
* Agree not to change current diet/exercise or not to use other medicines or supplements for sleep or anxiety other than the test product during entire study period.
* Agree not to participate in another clinical trial while enrolled in this trial

Exclusion Criteria

* Unstable or serious illness (e.g. serious mood disorders such as depression or bipolar disorder, neurological disorders such as MS, kidney disease, liver disease, GIT conditions, heart conditions, diabetes, thyroid gland function) (1)
* History of renal function impairment
* Regular sleeping pattern
* Current malignancy (excluding BCC) or chemotherapy or radiotherapy treatment for malignancy within the previous 2 years
* Receiving/prescribed coumadin (Warfarin), heparin, dalteparin, enoxaparin or other anticoagulation therapy
* Receiving/prescribed sleep or anxiety medication/aid
* Sleep apnea
* Diagnosed or consistent gastrointestinal issues that disrupt sleep
* Active smokers, nicotine use, drug abuse
* Chronic past and/or current alcohol use (\>14 alcoholic drinks week)
* Allergic to any of the ingredients in active or placebo formula
* People with serious mood disorders (such as depression, anxiety and bipolar disorder) will be excluded
* Those suffering from insomnia or have night-shift employment and unable to have a normal night's sleep (2)
* People suffering any neurological disorders such as MS
* Pregnant or lactating woman
* Any condition which in the opinion of the investigator makes the participant unsuitable for inclusion
* Participants who have participated in any other clinical trial during the past 6 months
* Clinically significant acute or chronic inflammation, or connective tissue disease or arthritis
* History of infection in the month prior to the study
* Regularly taking stimulants (e.g., coffee, caffeine supplements, caffeine containing beverages) 2 hours before bed
* Disturbed sleeping pattern caused by external factors (e.g., children, partner, noises)

1. An unstable illness is any illness that is currently not being treated with a stable dose of medication or is fluctuating in severity. A serious illness is a condition that carries a risk of mortality, negatively impacts quality of life and daily function and/or is burdensome in symptoms and/or treatments.
2. Insomnia has been excluded as it is a significant health condition, and we are testing on otherwise healthy participants (as per TGA complementary medicine requirements)
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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RDC Clinical Pty Ltd

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Amanda Rao, PhD

Role: PRINCIPAL_INVESTIGATOR

RDC Clinical Pty Ltd

Locations

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RDC Global Pty Ltd

Brisbane, Queensland, Australia

Site Status

Countries

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Australia

Other Identifiers

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MAGSLE

Identifier Type: -

Identifier Source: org_study_id

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