Visionary Study: Phase 3 Trial of Sibeprenlimab in Immunoglobulin A Nephropathy (IgAN)

NCT ID: NCT05248646

Last Updated: 2025-07-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

PHASE3

Total Enrollment

530 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-03-15

Study Completion Date

2026-12-30

Brief Summary

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This is a phase 3 study to evaluate effects on proteinuria and glomerular filtration rate of sibeprenlimab 400 mg subcutaneously (s.c.) Q 4 weeks in adults with IgAN who are receiving maximally tolerated standard-of-care therapy.

Detailed Description

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This is a multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of sibeprenlimab 400 mg administered SC Q 4 weeks compared to placebo in patients with IgAN. The primary objective is to compare the relative change from baseline in the urinary protein to creatinine ratio (uPCR) in 24-hour urine collections, after 9 months of treatment. The key secondary objective is to compare the annualized rate of change from baseline (slope) of estimated glomerular filtration rate (eGFR) after approximately 24 months of treatment. There will be one main cohort comprised of approximately 450 subjects with source-verified biopsy-confirmed IgAN and eGFR ≥ 30 mL/min/1.73 m\^2. An additional exploratory cohort will be comprised of up to 20 subjects with source-verified biopsy confirmed IgAN and eGFR of 20 to \< 30 mL/min/1.73 m\^2.

Conditions

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Immunoglobulin A Nephropathy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Sibeprenlimab 400 mg s.c. q 4weeks

Group Type ACTIVE_COMPARATOR

Sibeprenlimab 400 mg

Intervention Type DRUG

Sibeprenlimab 400 mg s.c. q 4 weeks

Placebo

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Placebo s.c. q 4 weeks

Interventions

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Sibeprenlimab 400 mg

Sibeprenlimab 400 mg s.c. q 4 weeks

Intervention Type DRUG

Placebo

Placebo s.c. q 4 weeks

Intervention Type DRUG

Other Intervention Names

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VIS649

Eligibility Criteria

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Inclusion Criteria

* Male and female patients ≥ 18 years of age .
* Biopsy-confirmed IgAN. (Patients with an eGFR of 30 to 45 mL/min/1.73m2 must have had a kidney biopsy performed within 36 months of the screening visit).
* Stable and maximally tolerated dose of ACEI and/or ARB for at least 3 months prior to screening. Patients who are on a stable dose of SGLT2i may participate if treatment was initiated ≥3 months prior to screening. Patients who are unable to take an ACEI or ARB may participate if their overall management conforms with standards of care and other protocol requirements.
* Screening urine protein/creatinine ratio (uPCR) ≥ 0.75 g/g or urine protein ≥ 1.0 g/day
* eGFR ≥ 30 mL/min/1.73 m2, (for the exploratory cohort only: eGFR 20- \<30 mL/min/1.73 m2), calculated using the CKD-EPI equation.)

Exclusion Criteria

* Secondary forms of IgAN or IgA vasculitis.
* Coexisting chronic kidney disease other than IgAN.
* Kidney biopsy findings in addition to IgAN including those of diabetic nephropathy, membranous nephropathy, or lupus nephritis. Hypertensive vascular changes are acceptable.
* Kidney biopsy MEST or MEST-C score of T2 or C2 (Oxford IgAN classification). If MEST-scoring was not performed, the presence of \> 50% tubulo-interstitial fibrosis, or crescents in \> 25% of glomeruli is exclusionary. This does not apply to the exploratory cohort.
* Nephrotic syndrome
* Serum IgG \< 600 mg/dL at screening.
* Chronic systemic immunosuppression, including glucocorticoids, within 16 weeks of randomization
* Participation in another interventional clinical trial and receipt of another investigational drug within 30 days prior to the administration of IMP or 5 half-lives from last investigational drug administration, whichever is longer.
* Chronic infectious disease, or acute infectious disease at time of screening.
* Type 1 diabetes, or poorly controlled Type 2 diabetes
* Uncontrolled hypertension
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Otsuka Pharmaceutical Development & Commercialization, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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University of Alabama at Birmingham - Site #336

Birmingham, Alabama, United States

Site Status

Mayo Clinic Arizona - Site #363

Phoenix, Arizona, United States

Site Status

University of Arkansas for Medical Sciences - Site #353

Little Rock, Arkansas, United States

Site Status

Amicis Research Center - Site #341

Granada Hills, California, United States

Site Status

University of CA San Diego - Site #351

La Jolla, California, United States

Site Status

California Institute of Renal Research - Site #371

La Mesa, California, United States

Site Status

Loma Linda University Health Care Clinical Trial Center Clinic - Site #372

Loma Linda, California, United States

Site Status

Academic Medical Research Institute - Site #333

Los Angeles, California, United States

Site Status

Kaiser Permanente - Southern California Permanente Medical Group SCPMG - LAMC - Site #325

Los Angeles, California, United States

Site Status

Stanford University - Site #370

Palo Alto, California, United States

Site Status

North America Research Institute - Site #335

San Dimas, California, United States

Site Status

University of California, San Francisco - Site #377

San Francisco, California, United States

Site Status

Colorado Kidney Care PC - Site #330

Denver, Colorado, United States

Site Status

Mayo Clinic in Florida - Site #321

Jacksonville, Florida, United States

Site Status

South Florida Research Institute - Site #323

Lauderdale Lakes, Florida, United States

Site Status

Columbus Research Group - Site #376

South Miami, Florida, United States

Site Status

Fides Clinical Research North Atlanta Kidney Specialists - Site #373

Atlanta, Georgia, United States

Site Status

Georgia Nephrology - Site #356

Lawrenceville, Georgia, United States

Site Status

University of Iowa Hospitals & Clinics - Site #359

Iowa City, Iowa, United States

Site Status

Kansas Nephrology Associates - Site #322

Wichita, Kansas, United States

Site Status

Ochsner Medical Center - Site #334

New Orleans, Louisiana, United States

Site Status

University of Maryland - Site #355

Baltimore, Maryland, United States

Site Status

MGH Harvard - Site #369

Boston, Massachusetts, United States

Site Status

Brigham and Women's Hospital, Division of Renal Medicine - Site #379

Boston, Massachusetts, United States

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Tufts Medical Center - Site #349

Boston, Massachusetts, United States

Site Status

Beth Israel Deaconess Medical Center - Site #337

Boston, Massachusetts, United States

Site Status

UMASS Memorial Medical Center - Site #331

Worcester, Massachusetts, United States

Site Status

St. Clair Nephrology Research - Site #320

Roseville, Michigan, United States

Site Status

University of Minnesota - Site #345

Minneapolis, Minnesota, United States

Site Status

Mayo Clinic - Rochester - Site #332

Rochester, Minnesota, United States

Site Status

University of Nebraska Medical Center - Site #347

Omaha, Nebraska, United States

Site Status

Davita Clinical Research - Las Vegas - Site #327

Las Vegas, Nevada, United States

Site Status

Northwell Health - North Shore University Hospital NSUH - Site #346

Great Neck, New York, United States

Site Status

New York University Grossman School of Medicine - Site #362

New York, New York, United States

Site Status

Jacobi Medical Center - Site #364

The Bronx, New York, United States

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The University of Cincinnati - Site #343

Cincinnati, Ohio, United States

Site Status

The Ohio State University Wexner Medical Center - Site #350

Columbus, Ohio, United States

Site Status

Rhode Island Hospital - Site #367

Providence, Rhode Island, United States

Site Status

Dunes Clinical Research LLC - Site #374

Dakota Dunes, South Dakota, United States

Site Status

Research Management, Inc - Site #354

Austin, Texas, United States

Site Status

Renal Disease Research Institute - Site #378

Dallas, Texas, United States

Site Status

Baylor College of Medicine (BCM) Medical Center - Site #375

Houston, Texas, United States

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Prolato Clinical Research Center (PCRC) - Site #324

Houston, Texas, United States

Site Status

Pioneer Research Solutions, Inc. - Site #339

Houston, Texas, United States

Site Status

UT Health Science Center at San Antonio - Site #368

San Antonio, Texas, United States

Site Status

Utah Kidney Research Institute - Site #342

Salt Lake City, Utah, United States

Site Status

University of Wisconsin - Site #352

Madison, Wisconsin, United States

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Medical College of Wisconsin - Site #361

Milwaukee, Wisconsin, United States

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Hospital Britanico de Buenos Aires - Site #800

Buenos Aires, , Argentina

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Maffei Centro Medico - Site #802

Buenos Aires, , Argentina

Site Status

Clinica Privada Velez Sarsfield - Nephrology and Transplantation Service - Site #801

Córdoba, , Argentina

Site Status

Centro de Salud Renal Junin S.R.L. - Site #803

Junín, , Argentina

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Canberra Hospital - Site #3

Garran, Australian Capital Territory, Australia

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Concord Repatriation General Hospital (CRGH) (Concord Hospital) - Site #13

Concord, New South Wales, Australia

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St. George Hospital - Site #14

Kogarah, New South Wales, Australia

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University of New South Wales (UNSW) - Liverpool Hosp - Site #11

Liverpool, New South Wales, Australia

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John Hunter Hospital - Site #5

New Lambton Heights, New South Wales, Australia

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Prince of Wales Hospital - Site #2

Randwick, New South Wales, Australia

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Royal North Shore Hospital - Site #6

Saint Leonards, New South Wales, Australia

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Royal Adelaide Hospital - Site #12

Adelaide, South Australia, Australia

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Flinders Medical Centre - Site #9

Bedford Park, South Australia, Australia

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Launceston General Hospital - Site #8

Launceston, Tasmania, Australia

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The University of Melbourne - St. Vincent's Hospital Melbourne (SVHM) - Site #1

Fitzroy, Victoria, Australia

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Western Health Sunshine Hospital - Site #10

St Albans, Victoria, Australia

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Fiona Stanley Hospital (FSH) - Site #4

Murdoch, Western Australia, Australia

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Sir Charles Gairdner Hospital - Site #7

Nedlands, Western Australia, Australia

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Hopital Erasme - Site #402

Brussels, , Belgium

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UZ Leuven Campus Gasthuisberg - Site #401

Genk, , Belgium

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Ziekenhuis Oost Limburg Genk ZOL - Site #405

Genk, , Belgium

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AZ Sint Lucas - Site #403

Ghent, , Belgium

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CHR de la Citadelle - Site #400

Liège, , Belgium

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Universidade Federal do CearClinic Pro-nefron - Site #827

Fortaleza, Ceará, Brazil

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Clinica Senhor do Bonfim Ltda CSB - Monte Serrat - Site #826

Salvador, Estado de Bahia, Brazil

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Recife - Site #820

Recife, Pernambuco, Brazil

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Santa Casa de Misericordia - Porto Alegre - Site #824

Porto Alegre, Rio Grande do Sul, Brazil

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Hospital de Clinicas de Porto Alegre HCPA - Site #828

Porto Alegre, Rio Grande do Sul, Brazil

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Fundacao Pro Rim - Site #821

Joinville, Santa Catarina, Brazil

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Centro de Pesquisa Medica Praxis - Site #825

Santo André, São Paulo, Brazil

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Faculdade de Medicina de Sao Jose do Rio Preto - SP FAMERP - Hospital de Base HB - Site #822

São José do Rio Preto, São Paulo, Brazil

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Universidade de Sao Paulo (USP) - Faculdade de Medicina (FMUSP) - Site #823

São Paulo, São Paulo, Brazil

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Universidade Federal de Sao Paulo - Escola Paulista de Medicina EPM - Hospital do Rim e Hipertensao HRIM - Site #830

São Paulo, São Paulo, Brazil

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Universidade estadual do Rio de Janeiro - Site #831

Rio de Janeiro, , Brazil

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University of Calgary - Health Research Innovation Centre: Sheldon Chumir Health Centre - Site #300

Calgary, Alberta, Canada

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St. Joseph's Healthcare Hamilton - Site #307

Hamilton, Ontario, Canada

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Clinical Research Solutions Inc. - Site #301

Kitchener, Ontario, Canada

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Lakeridge Health Oshawa - Site #303

Oshawa, Ontario, Canada

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OTT Healthcare Inc. - Site #305

Scarborough Village, Ontario, Canada

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Office of Stephen S. Chow, MD - Site #306

Toronto, Ontario, Canada

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CISSS de la Monteregie centre-Centre de recherche Hopital Charles Lemoyne - Site #302

Greenfield Park, Quebec, Canada

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McGill University Health Centre - Site #304

Montreal, Quebec, Canada

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Capital Medical University (CMU) - Beijing Anzhen Hospital (BAH) - Site #36

Beijing, Beijing Municipality, China

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Peking University People's Hospital - Site #32

Beijing, Beijing Municipality, China

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Peking University First Hospital - Site #20

Beijing, Beijing Municipality, China

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Peking University International Hospital - Site #34

Beijing, Beijing Municipality, China

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Beijing Tsinghua Changgung Hospital - Site #33

Beijing, Beijing Municipality, China

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Xiamen University - Zhongshan Hospital - Site #42

Xiamen, Fujian, China

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Sun Yat-sen Memorial Hospital - Site #39

Guangzhou, Guangdong, China

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The First Affiliated Hospital, Sun Yat - sen University - Site #40

Guangzhou, Guangdong, China

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The First Affiliated Hospital Of Guangzhou Medical University - Site #28

Guangzhou, Guangdong, China

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Peking University Shenzhen Hospital - Site #43

Shenzhen, Guangdong, China

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Liuzhou Workers Hospital - Site #35

Liuzhou, Guangxi, China

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The Peoples Hospital of Guangxi zhuang Autonomous Region - Site #27

Nanning, Guangxi, China

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Renmin Hospital of Wuhan University - Site #24

Wuhan, Hubei, China

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The Second Xiangya Hospital of Central South University - Site #44

Changsha, Hunan, China

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The First Affiliated Hospital of Baotou Medical University - Site #29

Baotou, Inner Mongolia Proviance, China

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Wuxi Peoples' Hospital affiliated to Nanjing Medical University - Site #30

Wuxi, Jiangsu, China

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The First Affiliated Hospital of Nanchang University - Site #22

Nanchang, Jiangxi, China

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Jiangxi Pingxiang Peoples' Hospital - Site #21

Pingxiang, Jiangxi, China

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The First Affiliated Hospital of Xi'an Jiaotong University - Site #31

Xi'an, Shaanxi, China

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The First Affiliated Hospital of Xi'an Medical College - Site #23

Xi'an, Shaanxi, China

Site Status

The First Affiliated Hospital of Shandong First Medical University (Qianfoshan Hospital of Shandong Province) - Site #26

Jinan, Shandong, China

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Yantai Yuhuangding Hospital - Site #41

Yantai, Shandong, China

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Sichuan Provincial Peoples Hospital - Site #38

Chengdu, Sichuan, China

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Yibin Second Peoples Hospital - Site #25

Yibin, Sichuan, China

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Zhejiang Provincial People's Hospital - Site #37

Hangzhou, Zhejiang, China

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University Hospital Center Osijek - Site #410

Osijek, , Croatia

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University Hospital Center Split - Site #413

Split, , Croatia

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Klinicka Bolnica Dubrava (KBD) (Clinical Hospital Dubrava) - Site #411

Zagreb, , Croatia

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University Hospital Merkur - Site #414

Zagreb, , Croatia

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Vseobecna fakultni nemocnice v Praze - Site #420

Prague, , Czechia

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Hopital Pellegrin - Site #431

Bordeaux, Aquitaine, France

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CHU de Grenoble Alpes - Hopital Nord Michallon - Site #433

Grenoble, Auvergne-Rhône-Alpes, France

Site Status

CHU Clermont-Ferrant-Gabriel Montpied - Site #443

Clermont-Ferrand, Auvergne, France

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CHU de Reims Hopital Maison Blanche - Site #442

Reims, Champagne-Ardenne, France

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Centre Hospitalier Universitaire de Nimes CHU - Hopital Universitaire Caremeau - Site #430

Nîmes, Gard, France

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Hopital Emile Muller - Site #438

Mulhouse, Haut-Rhin, France

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CHU Amiens-Picardie Nephrology Dialysis Transplantation - Site #440

Amiens, Hauts-de-France, France

Site Status

CHU Hotel Dieu, Nephrologie - Immunologie clinique - Transplantation - Site #432

Nantes, Loire-Atlantique, France

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CH Limoges - Site #439

Limoges, Nouvelle-Aquitaine, France

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Centre Hospitalier Universitaire de Saint-Etienne - Hopital Nord - Site #434

Saint-Priest-en-Jarez, Pays de la Loire Region, France

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Centre Hospitalier Henri Duffaut - Site #441

Avignon, Provence-Alpes-Côte d'Azur Region, France

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Hopital La Conception Centre de Nephrologie et de Transplantation Renal - Site #437

Marseille, Provence-Alpes-Côte d'Azur Region, France

Site Status

Assistance Publique-Hopitaux de Paris (AP-HP) - Hopitaux Universitaires Henri Mondor (Hopital Henri-Mondor) - Site #436

Créteil, Île-de-France Region, France

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Hopital de Tenon Sorbonne Universite - Site #435

Paris, Île-de-France Region, France

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Agaplesion Markus Krankenhaus - Site #457

Frankfurt am Main, Hesse, Germany

Site Status

DaVita Clinical Research Germany GmbH - Site #456

Düsseldorf, North Rhine-Westphalia, Germany

Site Status

Universitaetsmedizin Mainz - Site #455

Mainz, Rhineland-Palatinate, Germany

Site Status

Universitaetsklinikum Carl Gustav Carus - Site #450

Dresden, Saxony, Germany

Site Status

Hippokration General Hospital of Athens, Nephrology Clinic - Site #475

Athens, , Greece

Site Status

Nephrology Department, University General Hospital of Heraklion - Site #472

Heraklion, , Greece

Site Status

University Hospital of Ioannina (UHI) - Nephrology Clinic - Site #471

Ioannina, , Greece

Site Status

University of Thessaly, Nephrology Clinic - Site #474

Larissa, , Greece

Site Status

Aristotle University of Thessaloniki (AUTH) - Hippokration Hospital - Site #470

Thessaloniki, , Greece

Site Status

Hellenic Republic Ministry of Health & Welfare - General Hospital of Thessaloniki (George Papanikolaou) - Site #473

Thessaloniki, , Greece

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Queen Mary Hospital - Site #60

Hong Kong, , Hong Kong

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Tung Wah Hospital - Site #61

Hong Kong, , Hong Kong

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Princess Margaret Hospital - Site #62

Kowloon, , Hong Kong

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Prince of Wales Hospital - Site #63

Shatin, , Hong Kong

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Yan Chai Hospital - Site #64

Tsuen Wan, , Hong Kong

Site Status

Pecsi Tudomanyegyetem, Altalanos Orvostudomanyi KarKlinikai Kozpont II - Site #482

Pécs, Baranya, Hungary

Site Status

Somogy Megyei Kaposi Mor Oktatokorhaz - Site #481

Kaposvár, Somogy County, Hungary

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Kusum Dhirajlal Hospital - Site #73

Ahmedabad, Gujarat, India

Site Status

Muljibhai Patel Urological Hospital (MPUH) (Kidney Hospital) - Site #70

Nadiād, Gujarat, India

Site Status

M.S. Ramaiah Memorial Hospital - Site #72

Bengaluru, Karnataka, India

Site Status

Mazumdar Shaw Medical Centre - A unit of Narayana Health - Site #87

Bengaluru, Karnataka, India

Site Status

Manipal University - Kasturba Medical College - Site #79

Manipal, Karnataka, India

Site Status

Government Medical College - Site #71

Kozhikode, Kerala, India

Site Status

Government Medical College Thiruvananthapuram - Site #74

Thiruvananthapuram, Kerala, India

Site Status

Mahatma Gandhi Mission Institute of Health Scienes MGMIHS - Mahatma Gandhi Mission MGM Medical Centre Research Institute - Aurangabad - Site #82

Aurangabad, Maharashtra, India

Site Status

Life Point Multispecialty Hospital - Site #84

Pune, Maharashtra, India

Site Status

Sir Ganga Ram Hospital - Site #75

New Delhi, National Capital Territory of Delhi, India

Site Status

Postgraduate Institute of Medical Education Research PGIMER - Site #77

Chandigarh, Punjab, India

Site Status

Christian Medical College & Hospital (CMCH) - Vellore - Site #80

Vellore, Tamil Nadu, India

Site Status

Osmania General Hospital (OGH) - Site #78

Hyderabad, Telangana, India

Site Status

Nizams Institute of Medical Sciences NIMS - Site #81

Hyderabad, Telangana, India

Site Status

Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS) - Site #76

Lucknow, Uttar Pradesh, India

Site Status

The Barzilai Medical Center (The Ashkelon Hospital) - Site #494

Ashkelon, , Israel

Site Status

Technion-Israel Institute of Technology - The Lady Davis Carmel Medical Center (LDCMC) - Institute of Nephrology and Hypertension - Site #491

Haifa, , Israel

Site Status

Shaare Zedek Medical Center (SZMC) - Site #492

Jerusalem, , Israel

Site Status

Tel Aviv University Sackler School of Medicine - Meir Medical Center (MMC) (Meir Hospital) - Site #490

Kfar Saba, , Israel

Site Status

Galilee Medical Center (Western Galilee Hospital) - Site #495

Nahariya, , Israel

Site Status

Rabin Medical Center - Institute of Nephrology and Hypertension - Diabetic Nephropathy Clinic - Site #493

Petah Tikva, , Israel

Site Status

IRCCS Azienda Ospedaliero-Universitaria Policlinico Sant Orsola - Site #512

Bologna, , Italy

Site Status

Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia - Site #504

Brescia, , Italy

Site Status

Azienda Ospedaliero-Universitaria Careggi Firenze - Site #500

Florence, , Italy

Site Status

Ospedale San Giovanni di Dio - Site #506

Florence, , Italy

Site Status

Clinica Nefrologica, Dialisi e Trapianto, IRCCS Ospedale Policlinico San Martino - Site #503

Genova, , Italy

Site Status

AOU Gaetano Martino di Messina U.O.C., Nefrologia e Dialisi - Site #502

Messina, , Italy

Site Status

Fondazione IRCCS Ca'Granda Ospedale Maggiore Policlinico - Site #513

Milan, , Italy

Site Status

Campania Luigi Vanvitelli - Site #510

Napoli, , Italy

Site Status

Fondazione Maugeri - Site #509

Pavia, , Italy

Site Status

AUSL Hospital Guglielmo da Saliceto - Site #507

Piacenza, , Italy

Site Status

Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Site #501

Roma, , Italy

Site Status

ULSS 6 Vicenza - Ospedale San Bortolo di Vicenza - Site #505

Vicenza, , Italy

Site Status

Ospedale di Belcolle Viterbo - Site #514

Viterbo, , Italy

Site Status

Nagoya University Hospital - Site #705

Nagoya, Aichi-ken, Japan

Site Status

Fujita Health University Hospital - Site #709

Toyoake, Aichi-ken, Japan

Site Status

Juntendo University - Urayasu Hospital - Site #707

Urayasu, Chiba, Japan

Site Status

Kurume University Hospital - Site #725

Kurume, Fukuoka, Japan

Site Status

Hyogo Prefectural Amagasaki General Medical Center (Hyogo AGMC) - Site #723

Amagasaki, Hyōgo, Japan

Site Status

Kobe University Hospital - Site #724

Kobe, Hyōgo, Japan

Site Status

University of Tsukuba Hospital - Site #708

Tsukuba, Ibaraki, Japan

Site Status

Kanazawa University Hospital - Site #702

Kanazawa, Ishikawa-ken, Japan

Site Status

Toranomon Hospital Kajigaya - Site #714

Kawasaki, Kanagawa, Japan

Site Status

Kitasato University Hospital - Site #729

Sagamihara, Kanagawa, Japan

Site Status

Tohoku Medical and Pharmaceutical University Hospital - Site #718

Sendai, Miyagi, Japan

Site Status

Nara Medical University Hospital - Site #713

Kashihara, Nara, Japan

Site Status

Juntendo University Nerima Hospital - Site #727

Tokyo, Nerima-ku, Japan

Site Status

Oita University Hospital - Site #717

Yufu, Oita Prefecture, Japan

Site Status

Osaka University Hospital - Site #719

Suita, Osaka, Japan

Site Status

Hamamatsu University Hospital - Site #704

Hamamatsu, Shizuoka, Japan

Site Status

Japanese Red Cross Ashikaga Hospital - Site #726

Ashikaga, Tochigi, Japan

Site Status

Juntendo University Hospital - Site #715

Bunkyō-Ku, Tokyo, Japan

Site Status

The Jikei University Hospital - Site #712

Minato-Ku, Tokyo, Japan

Site Status

Tokyo Medical University Hospital - Site #728

Shinjuku-Ku, Tokyo, Japan

Site Status

Tokyo Women's Medical University Hospital - Site #710

Shinjuku-Ku, Tokyo, Japan

Site Status

Teikyo University Hospital - Site #706

tabashi City, Tokyo, Japan

Site Status

NHO Chibahigashi National Hospital - Site #700

Chiba, , Japan

Site Status

Kyushu University Hospital (KUH) - Site #703

Fukuoka, , Japan

Site Status

Fukuoka University - Fukuoka University Hospital - Site #722

Fukuoka, , Japan

Site Status

University of Miyazaki Hospital - Site #716

Miyazaki, , Japan

Site Status

Nagasaki University Hospital - Site #720

Nagasaki, , Japan

Site Status

Niigata University Medical & Dental Hospital - Site #711

Niigata, , Japan

Site Status

Okayama University Hospital - Site #701

Okayama, , Japan

Site Status

Osaka General Medical Center - Site #721

Osaka, , Japan

Site Status

Hospital Kuala Lumpur - Site #123

Kuala Lumpur, Kuala Lumpur, Malaysia

Site Status

Hospital Canselor Tuanku Muhriz UKM - Site #125

Kuala Lumpur, Kuala Lumpur, Malaysia

Site Status

University Malaya Medical Centre - Site #121

Kuala Lumpur, Kuala Lumpur, Malaysia

Site Status

Hospital Tuanku Ja'afar - Site #122

Seremban, Negeri Sembilan, Malaysia

Site Status

Hospital Tengku Ampuan Afzan - Site #120

Kuantan, Pahang, Malaysia

Site Status

Hospital Raja Permaisuri Bainun - Site #124

Ipoh, Perak, Malaysia

Site Status

Sunway Medical Centre (SMC) - Site #126

Petaling Jaya, Selangor, Malaysia

Site Status

Radboud Universitair Medisch Centrum - Site #520

Nijmegen, Gelderland, Netherlands

Site Status

Maastricht University Medical Center (MUMC) - Site #523

Maastricht, Limburg, Netherlands

Site Status

Groene Hart Ziekenhuis, Ioc, Bleuland - Site #521

Gouda, South Holland, Netherlands

Site Status

Amsterdam UMC - Site #522

Amsterdam, , Netherlands

Site Status

University of Santo Tomas Hospital - Site #130

Manila, , Philippines

Site Status

National Kidney Institute - Site #132

Quezon, , Philippines

Site Status

St. Luke's Medical Center - Quezon City - Site #131

Quezon, , Philippines

Site Status

Uniw. Szp. Kliniczny w Bialymstoku, 2nd Department of Nephrology and Hypertension with Dialysis Unit - Site #531

Bialystok, Bialystok, Poland

Site Status

Szpital Uniwersytecki w Krakowie - Site #533

Krakow, Lesser Poland Voivodeship, Poland

Site Status

Centrum Medyczne PROMED - Site #535

Krakow, Malopotskie, Poland

Site Status

Centralny Szpital Kliniczny Uniwersytetu Medycznego w odzi - Site #530

Lodz, Łódź Voivodeship, Poland

Site Status

Centro Clinico Academico - Braga - Site #540

Braga, , Portugal

Site Status

Centro Hospitalar de Lisboa Ocidental (CHLO), E.P.E. - Hospital de Santa Cruz (HSC) - Site #545

Carnaxide, , Portugal

Site Status

Hospital Beatriz Angelo (HBA) - Site #541

Lisbon, , Portugal

Site Status

Servico de Nefrologia - Centro Hospitalar Universitario Sao Joao (CHUSJ), EPE - Site #544

Porto, , Portugal

Site Status

Centro Hospitalar de Vila Nova de Gaia / Espinho - Site #543

Porto, , Portugal

Site Status

National University Hospital - Site #142

Singapore, Central Singapore, Singapore

Site Status

Singapore General Hospital (SGH) - Site #141

Singapore, Central Singapore, Singapore

Site Status

Tan Tock Seng Hospital - Site #140

Singapore, Central Singapore, Singapore

Site Status

Pusan National University Hospital - Site #102

Busan, Busan Gwang'yeogsi, South Korea

Site Status

Kyungpook National UniversityA Hospital - Site #112

Daegu, Daegu Gwang'yeogsi, South Korea

Site Status

Chonnam National University Hospital - Site #113

Gwangju, Gwangiu Gwang'yeogsi, South Korea

Site Status

National Health Insurance Service Ilsan Hospital - Site #114

Goyang-si, Gyeonggi-do, South Korea

Site Status

Hallym University Medical Center - Sacred Heart Hospital - Site #104

Anyang, Gyeonggido, South Korea

Site Status

Hallym University Medical Center - Dongtan Sacred Heart Hospital - Site #109

Hwasŏng, Gyeonggido, South Korea

Site Status

Seoul National University Bundang Hospital - Site #110

Seongnam, Gyeonggido, South Korea

Site Status

Asan Medical Center (AMC) - Site #111

Seoul, Seoul Teugbyeoisi, South Korea

Site Status

Kyung Hee University International Medical Service Gangdong Kyung Hee University KHU - Site #105

Seoul, Seoul Teugbyeolsi, South Korea

Site Status

Seoul National University Hospital - Site #107

Seoul, Seoul Teugbyeolsi, South Korea

Site Status

Konkuk University Medical Center - Site #108

Seoul, Seoul Teugbyeolsi, South Korea

Site Status

Kangdong Sacred Heart Hospital - Site #106

Seoul, Seoul Teugbyeolsi, South Korea

Site Status

Samsung Medical Center - Site #100

Seoul, Seoul Teugbyeolsi, South Korea

Site Status

Yonsei University Severance Hospital - Site #103

Seoul, Seoul Tukpyolshi, South Korea

Site Status

Hospital Universitario de A Corua - Site #569

A Coruña, , Spain

Site Status

Hospital Universitario Cruces - Site #574

Barakaldo, , Spain

Site Status

Hospital del Mar - Site #572

Barcelona, , Spain

Site Status

Fundacio Puigvert - Site #567

Barcelona, , Spain

Site Status

Hospital Universitari Vall d'Hebron - Site #566

Barcelona, , Spain

Site Status

Hospital Universitari de Bellvitge - Site #563

Barcelona, , Spain

Site Status

Hospital Clinico San Carlos - Site #564

Bilbao, , Spain

Site Status

Hospital Universitario Reina Sofia - Site #565

Córdoba, , Spain

Site Status

Hospital Arquitecto Marcide de Ferrol - Site #575

Ferrol, , Spain

Site Status

Hospital Universitario Puerta de Hierro - Site #570

Madrid, , Spain

Site Status

Hospital Universitario Marques de Valdecilla - Site #560

Santander, , Spain

Site Status

Hospital Universitario Virgen Macarena - Site #562

Seville, , Spain

Site Status

Hospital Universitario Virgen del Rocio - Site #561

Seville, , Spain

Site Status

Hospital Universitario Dr. Peset - Site #568

Valencia, , Spain

Site Status

National Hospital of Sri Lanka - Site #151

Colombo, , Sri Lanka

Site Status

Karapitiya Teaching Hospital - Site #153

Galle, , Sri Lanka

Site Status

National Hospital Kandy - Site #152

Kandy, , Sri Lanka

Site Status

Kurunegala Teaching Hospital - Site #154

Kurunegala, , Sri Lanka

Site Status

Sri Jayewardenepura General Hospital (SJGH) - Site #150

Nugegoda, , Sri Lanka

Site Status

Kaohsiung Chang Gung Memorial Hospital - Site #161

Kaohsiung City, , Taiwan

Site Status

Keelung Chang Gung Memorial Hospital - Site #160

Keelung, , Taiwan

Site Status

Shuang Ho Hospital - Site #163

New Taipei City, , Taiwan

Site Status

Taichung Veterans General Hospital - Site #162

Taichung, , Taiwan

Site Status

National Taiwan University Hospital - Site #164

Taipei, , Taiwan

Site Status

Taipei Veterans General Hospital - Site #165

Taipei, , Taiwan

Site Status

Navamindradhiraj University - Site #174

Bangkok, , Thailand

Site Status

King Chula Memorial Hospital, Chulalongkorn University - Site #170

Bangkok, , Thailand

Site Status

Phramongkutklao Hospital - Site #175

Bangkok, , Thailand

Site Status

Ramathibodi Hospital - Site #171

Bangkok, , Thailand

Site Status

Chiang Mai University - Site #172

Chiang Mai, , Thailand

Site Status

Khon Kaen University - Site #173

Khon Kaen, , Thailand

Site Status

Cambridge University Hospitals NHS Foundation Trust - Site #580

Cambridge, , United Kingdom

Site Status

Gloucestershire Royal Hospital - Site #586

Gloucester, , United Kingdom

Site Status

University Hospitals of Leicester NHS Trust - Site #581

Leicester, , United Kingdom

Site Status

Barts Health NHS Trust - The Royal London Hospital - Site #584

London, , United Kingdom

Site Status

Royal Free Hospital London NHS Trust - Site #585

London, , United Kingdom

Site Status

King's College Hospital, NHS Foundation Trust - Site #582

London, , United Kingdom

Site Status

Salford Royal NHS Foundation Trust - Site #583

Salford, , United Kingdom

Site Status

Clinical Research Unit, Morriston Hospital - Site #588

Swansea, , United Kingdom

Site Status

Viet Duc Hospital - Site #181

Hanoi, , Vietnam

Site Status

Nguyen Tri Phuong Hospital - Site #180

Ho Chi Minh City, , Vietnam

Site Status

Hue Central Hospital - Site #182

Huế, , Vietnam

Site Status

Countries

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United States Argentina Australia Belgium Brazil Canada China Croatia Czechia France Germany Greece Hong Kong Hungary India Israel Italy Japan Malaysia Netherlands Philippines Poland Portugal Singapore South Korea Spain Sri Lanka Taiwan Thailand United Kingdom Vietnam

References

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Ahmad SB, Jefferson JA. Targeting B Cells and Plasma Cells in Glomerular Disease. J Am Soc Nephrol. 2025 Jun 4;36(9):1844-1857. doi: 10.1681/ASN.0000000772.

Reference Type DERIVED
PMID: 40465397 (View on PubMed)

Other Identifiers

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417-201-00007

Identifier Type: -

Identifier Source: org_study_id

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