Study of CM313 in Subject With IgA Nephropathy

NCT ID: NCT06830395

Last Updated: 2025-09-19

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Clinical Phase: PHASE2
• Total Enrollment: 106 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2025-09-30
• Study Completion Date: 2028-08-31

Brief Summary

This study is divided into two parts (Part A and Part B). This study aims to evaluate the safety and efficacy of CM313 in subjects with primary Immunoglobulin A nephropathy(IgAN), while also observing its Pharmacokinetics(PK) characteristics, Pharmacokinetics(PD) effects, and immunogenicity.

Conditions

IgA Nephropathy

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: QUADRUPLE

Study Groups

Part A: CM313 low dose

Group Type: EXPERIMENTAL

CM313

Intervention Type: BIOLOGICAL

CM313(SC) injection

Part A: CM313 high dose

Group Type: EXPERIMENTAL

CM313

Intervention Type: BIOLOGICAL

CM313(SC) injection

Part B: CM313 low dose with low frequency

Group Type: EXPERIMENTAL

CM313

Intervention Type: BIOLOGICAL

CM313(SC) injection

Part B: CM313 low dose with high frequency

Group Type: EXPERIMENTAL

CM313

Intervention Type: BIOLOGICAL

CM313(SC) injection

Part B: Placebo matching the volume of low dose CM313

Group Type: PLACEBO_COMPARATOR

Placebo

Intervention Type: DRUG

Matched placebo

Part B: CM313 high dose with low frequency

Group Type: EXPERIMENTAL

CM313

Intervention Type: BIOLOGICAL

CM313(SC) injection

Part B: CM313 high dose with high frequency

Group Type: EXPERIMENTAL

CM313

Intervention Type: BIOLOGICAL

CM313(SC) injection

Part B: Placebo matching the volume of high dose CM313

Group Type: PLACEBO_COMPARATOR

Placebo

Intervention Type: DRUG

Matched placebo

Interventions

CM313

CM313(SC) injection

Intervention Type: BIOLOGICAL

Placebo

Matched placebo

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• Able to comprehend the research study and voluntarily signing the informed consent form (ICF).
• Renal biopsy report supporting diagnosis of primary IgAN within 8 years prior to the screening visit.
• Estimated Glomerular Filtration Rate (eGFR) (using the Chronic Kidney Disease Epidemiology Collaboration formula) ≥ 30 mL/min/1.73 (m*m) at screening and baseline.
• Prior to the baseline visit, all subjects must have received standard care treatment, including good blood pressure control and a stable treatment of a maximum recommended or maximum tolerated dose of angiotensin-converting enzyme inhibitors(ACEI) or Angiotensin receptor blocker(ARB) for at least 12 weeks.
• 24-hour urinary protein-to-creatinine ratio (24h-UPCR) ≥ 0.75 g/g or 24-hour urinary protein excretion (24h-UPE) ≥ 1 g/d during the screening and baseline periods.

Exclusion Criteria

• Secondary IgAN judged by the investigator: Secondary IgAN may be associated with Henoch-Schonlein purpura, hepatic cirrhosis, coeliac disease, human immunodeficiency virus (HIV) infection, dermatitis herpetiformis, seronegative arthritis, small cell carcinoma, lymphoma, disseminated tuberculosis, obliterative bronchiolitis, inflammatory bowel disease, familial Mediterranean fever, etc.
• Known allergy to monoclonal antibody drugs or to the excipients of CM313.
• Presence of rapidly progressive glomerulonephritis (RPGN), defined as 50% decline in eGFR within 3 months prior to randomization and/or crescent formation in more than 50% of glomeruli in a renal pathological specimen.
• Confirmed acute kidney injury (AKI) within 4 weeks prior to randomization.
• Vaccination of any live vaccine within 30 days prior to dosing or planned vaccination during the study period.
• History of transplantation (any solid organ transplant, including renal transplant, bone marrow transplant, etc.) or plan to undergo renal transplantation during the study.
• History of severe recurrent or chronic infection.
• Malignant tumor within 5 years prior to screening (except for completely cured cervix carcinoma in situ and non-skin squamous cell carcinoma metastatic or basal cell carcinoma).

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Keymed Biosciences Co.Ltd

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Jicheng Lv

Role: PRINCIPAL_INVESTIGATOR

Peking University Frist Hospital

Locations

Peking University First Hospital

Beijing, Beijing Municipality, China

Countries

China

Central Contacts

Qian Jia

Role: CONTACT

qianjia@keymedbio.com

028-88610620

Other Identifiers

CM313-105101

Identifier Type: -

Identifier Source: org_study_id