Propofol/Dexmedetomidine Versus Desflurane Effects on Post Hepatectomy Hepatocellular Injury
NCT ID: NCT05246371
Last Updated: 2023-01-18
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
UNKNOWN
EARLY_PHASE1
30 participants
INTERVENTIONAL
2021-06-01
2023-11-30
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Hemodynamic Responses of Dexmedetomidine, Lidocaine or Propofol Infusions During Laparoscopic Cholecystectomy
NCT05937282
Dexmedetomidine-ketamine Versus Propofol-ketamine for Sedation During Endoscopy in Hepatic Patients
NCT04906772
Effect of Dexmedetomidine and Propofol on Regional Cerebral Tissue Oxygen Saturation
NCT03817112
Propofol Versus Dexmedetomidine for Prevention of Sevoflurane Agitation in Recipients of Living Donor Liver Transplantation
NCT02544906
Efficacy of Propofol Combination With Either Ketamine, Dexmedetomidine or Midazolam for Sedation During Upper Gastrointestinal Endoscopic Procedures
NCT07190612
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
Anesthetic agents used in general anesthesia for liver surgery have a big effect on hepatic blood flow, oxygen delivery and liver function This study will compare the effects of propofol/dexmedetomidine versus desflurane for maintenance of general anesthesia on hepatocellular injury in patients undergoing partial hepatectomy.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
RANDOMIZED
PARALLEL
PREVENTION
NONE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
propofol and dexmedetomidine
Patients will receive maintenance of general anesthesia by TIVA using combination of propofol and dexmedetomidine
Propofol, dexmedetomidine
Patients will receive maintenance of general anesthesia by TIVA using combination of propofol and dexmedetomidine.
desflurane
Patients will receive maintenance of general anesthesia by desflurane.
Desflurane
Patients will receive maintenance of general anesthesia by desflurane.
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
Propofol, dexmedetomidine
Patients will receive maintenance of general anesthesia by TIVA using combination of propofol and dexmedetomidine.
Desflurane
Patients will receive maintenance of general anesthesia by desflurane.
Other Intervention Names
Discover alternative or legacy names that may be used to describe the listed interventions across different sources.
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
2. Patients Child Pugh classification A to B.
3. Both sexes.
4. Aged between 18 years and 70 years
5. Scheduled for more than 1 segment hepatectomy.
Exclusion Criteria
2. Patients younger than18 years old or older than 70 years old
3. Patients performed additional ablation therapies (cryosurgery or radiofrequency ablation).
4. Prior liver resection for donation.
5. Scheduled resection not requiring inflow occlusion (Pringle's maneuver).
6. Hypersensitivity to any of the used drugs.
18 Years
70 Years
ALL
No
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
Ain Shams University
OTHER
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Principal Investigators
Learn about the lead researchers overseeing the trial and their institutional affiliations.
Hany Alzahaby, Professor
Role: STUDY_CHAIR
Ain Shams University
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
Ain Shams University
Cairo, , Egypt
Countries
Review the countries where the study has at least one active or historical site.
Central Contacts
Reach out to these primary contacts for questions about participation or study logistics.
Facility Contacts
Find local site contact details for specific facilities participating in the trial.
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
Ain Shams anesthesia Dep
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.