Developmental Coordination Disorder

NCT ID: NCT05154799

Last Updated: 2026-01-16

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: NA
• Total Enrollment: 280 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2021-12-21
• Study Completion Date: 2027-01-21

Brief Summary

Developmental Coordination Disorder (DCD) corresponds to a clumsiness, a slowness and an inaccuracy of motor performance. This neurodevelopmental disorder affects 6% of school-aged children, and disturbs daily life activities and academic performances. The etiology of DCD is still unknown. An understanding of this disorder is necessary to improve interventions and therefore quality of life of these people.

A deficit of the so-called internal models is the most commonly described hypothesis of DCD. Indeed, children with DCD exhibit difficulties in predictive control. Internal models, useful for motor control, are closely related to the sensory system, as they are elaborated on and constantly fed by sensory feedback. Deficits in sensory performance are described in DCD, mostly in the visual system, which could in turn partly explain poor motor performance. However, visuo-perceptual deficits cannot explain the entire motor difficulties because some activities in daily life, as buttoning a shirt, are often performed without visual control. Although the integrity of proprioceptive and tactile systems is necessary for the building of internal models, and therefore for a stable motor control, these sensory systems have been very little investigated in DCD.

Moreover, using a tool is often disturbed in children with DCD. In neurotypical subjects, tool use induces a plasticity of body representation, as reflected by modifications of movement kinematics after tool use. Proprioceptive abilities are necessary for this update of the body schema. Thus, potential deficits of the proprioceptive system in children with DCD could impair the plastic modification of the body schema, and hence of motor performance, when using a tool. The aim of this study is to identify the main cause of the DCD, both by evaluating the tactile and proprioceptive abilities and by assessing the body schema updating abilities in children with DCD.

While some daily life activities improve with age, some motor difficulties persist in adults with DCD. To our knowledge, perceptual abilities have never been investigated in adults with DCD and it is thus unknown whether perceptual deficits are still present in adulthood. This information could allow us to understand if motor difficulties in adult DCD are caused by enduring perceptual deficits and/or impaired plasticity of body schema. The second aim of this study is to evaluate abilities of perception and of body schema plasticity in adults with DCD.

Conditions

Motor Skills Disorders; Neurodevelopmental Disorders

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: FACTORIAL
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: NONE

Study Groups

Dyspraxic children

Children with Developmental coordination disorder

Group Type: EXPERIMENTAL

Proprioception and tactile localization with manual or ocular response and/or free hand grasp

Intervention Type: BEHAVIORAL

In the first part of the study, the subject must designate a target in 2 ways: manual pointing or ocular saccadic response.

In the second part of the study the subject will have to reach and grasp a rectangular block of wood placed on the table at a distance of 35 cm. He will have to catch the wooden block, lift it a few centimeters and put it back on the table. Tool use and control phases: the subject grasps the wooden block with a tool or without the tool but with a weighted bracelet loading his wrist by the same amount as the tool.

Control children

Healthy children

Group Type: EXPERIMENTAL

Proprioception and tactile localization with manual or ocular response and/or free hand grasp

Intervention Type: BEHAVIORAL

In the first part of the study, the subject must designate a target in 2 ways: manual pointing or ocular saccadic response.

In the second part of the study the subject will have to reach and grasp a rectangular block of wood placed on the table at a distance of 35 cm. He will have to catch the wooden block, lift it a few centimeters and put it back on the table. Tool use and control phases: the subject grasps the wooden block with a tool or without the tool but with a weighted bracelet loading his wrist by the same amount as the tool.

Dyspraxic adults

Adults with with Developmental coordination disorder

Group Type: EXPERIMENTAL

Proprioception and tactile localization with manual or ocular response and/or free hand grasp

Intervention Type: BEHAVIORAL

In the first part of the study, the subject must designate a target in 2 ways: manual pointing or ocular saccadic response.

In the second part of the study the subject will have to reach and grasp a rectangular block of wood placed on the table at a distance of 35 cm. He will have to catch the wooden block, lift it a few centimeters and put it back on the table. Tool use and control phases: the subject grasps the wooden block with a tool or without the tool but with a weighted bracelet loading his wrist by the same amount as the tool.

Control adults

Control adults

Group Type: EXPERIMENTAL

Proprioception and tactile localization with manual or ocular response and/or free hand grasp

Intervention Type: BEHAVIORAL

In the first part of the study, the subject must designate a target in 2 ways: manual pointing or ocular saccadic response.

In the second part of the study the subject will have to reach and grasp a rectangular block of wood placed on the table at a distance of 35 cm. He will have to catch the wooden block, lift it a few centimeters and put it back on the table. Tool use and control phases: the subject grasps the wooden block with a tool or without the tool but with a weighted bracelet loading his wrist by the same amount as the tool.

Interventions

Proprioception and tactile localization with manual or ocular response and/or free hand grasp

In the first part of the study, the subject must designate a target in 2 ways: manual pointing or ocular saccadic response.

In the second part of the study the subject will have to reach and grasp a rectangular block of wood placed on the table at a distance of 35 cm. He will have to catch the wooden block, lift it a few centimeters and put it back on the table. Tool use and control phases: the subject grasps the wooden block with a tool or without the tool but with a weighted bracelet loading his wrist by the same amount as the tool.

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• Male or female
• Aged 9 to 11 or 18 to 40
• Affiliated to a health care organism
• Signed written informed consent (adult subjects)
• One of the legal guardians of children subjects providing their free, informed and written consent to participate in the study; With the child also giving orally his consent to participate.

For participants with Developmental coordination disorder:

• Subjects fulfilling the diagnostic criteria for dyspraxia of DSM-5 (these criteria will be verified by the principal investigator)
• Total MABC-2 score below the 15th percentile (if this MABC-2 assessment is already available).

Exclusion Criteria

• Prematurity
• Known neurological pathology (other than dyspraxia)
• Intellectual disability
• Visual impairment
• Surgery or trauma to the upper limbs that has occurred too recently to allow proper testing
• Subject under tutorship or curatorship
• Subject deprived of liberty by a judicial or administrative decision

For healthy volunteers only:

• History of developmental coordination disorder in close relatives (parents, children, siblings).

• Minimum Eligible Age: 9 Years
• Maximum Eligible Age: 40 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Hospices Civils de Lyon

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Denis PELISSON, Dr

Role: PRINCIPAL_INVESTIGATOR

Centre de Recherche en Neurosciences de Lyon

Locations

Equipe IMPACT du CRNL INSERM U1028, CNRS UMR 5292

Bron, Auvergne-Rhône-Alpes, France

Site Status: RECRUITING

Countries

France

Central Contacts

Alessandro FARNE, Dr

Role: CONTACT

alessandro.farne@inserm.fr

4 72 91 34 17 ext. +33

Marion NAFFRECHOUX, PhD Student

Role: CONTACT

marion.naffrechoux@inserm.fr

6 38 64 54 60 ext. +33

Facility Contacts

Alessandro Farne, Dr

Role: primary

alessandro.farne@inserm.fr

4 72 91 34 17 ext. +33

Other Identifiers

69HCL21_0338

Identifier Type: -

Identifier Source: org_study_id