Limb Injuries and Post Injury Rehabilitation Trials - Tibial Shaft Fracture

NCT ID: NCT05151926

Last Updated: 2025-01-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

240 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-12-03

Study Completion Date

2027-12-31

Brief Summary

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Aim of our study is to compare immediate full weight-bearing and partial weight-bearing for 6 weeks after a tibial shaft fracture treated with intramedullary nailing. Co-primary outcome is return to work and physical component scale in the SF-36 questionnaire.

Detailed Description

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Conditions

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Tibia Fracture

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Randomized controlled clinical trial
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Full weight-bearing

Full immediate weight-bearing postoperatively

Group Type EXPERIMENTAL

Full weight-bearing

Intervention Type PROCEDURE

Instruction for full and immediate weight-bearing postoperatively

Intramedullary nailing

Intervention Type PROCEDURE

Intramedullary nailing of the fractured tibial shaft.

Partial-weight bearing

Partial weight-bearing for the first 6 weeks postoperatively.

Group Type ACTIVE_COMPARATOR

Partial weight-bearing

Intervention Type PROCEDURE

Instruction for partial weight-bearing for 6 weeks postoperatively

Intramedullary nailing

Intervention Type PROCEDURE

Intramedullary nailing of the fractured tibial shaft.

Interventions

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Full weight-bearing

Instruction for full and immediate weight-bearing postoperatively

Intervention Type PROCEDURE

Partial weight-bearing

Instruction for partial weight-bearing for 6 weeks postoperatively

Intervention Type PROCEDURE

Intramedullary nailing

Intramedullary nailing of the fractured tibial shaft.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* AO/OTA 42-A/B acute, noncomminuted diaphyseal fracture of the tibia treated with intramedullary nailing with or without posterior malleolus screw fixation
* operated within 72 hours of admittance
* age between 18-65 years

Exclusion Criteria

* the inability to fill out the Finnish versions of the questionnaires
* previous arthroplasty of the knee or the ankle of the fractured limb
* previous ipsilateral below-knee fracture requiring surgical treatment or ankle arthrodesis
* inability to co-operate
* not living independently (institutionalized living before fracture)
* open fracture (Gustilo grade 2 or over)
* pathologic or stress fracture
* multiple fractures requiring operative treatment in polytrauma patient
* severe medical comorbidity impairing daily activities (inability to go climb three floors without assistance and stopping)
* Body Mass Index over 40
* unacceptably high risk of surgery due to severe medical comorbidities
* severe substance abuse
* patient is retired
* age is less than 18 or more than 65
* patient required a fasciotomy due to acute compartment syndrome during or after index surgery
* inability to walk before fracture or a daily need of walking aid, such as crutches
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Tampere University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Aleksi Reito

Associate professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Aleksi Reito, Assoc prof

Role: PRINCIPAL_INVESTIGATOR

Tampere University Hospital

Locations

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Central Finland Hospital Nova

Jyväskylä, Central Finland, Finland

Site Status NOT_YET_RECRUITING

Tampere Univeristy Hospital

Tampere, Pirkanmaa, Finland

Site Status RECRUITING

Turku University Hospital

Turku, Southwest Finland, Finland

Site Status NOT_YET_RECRUITING

Countries

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Finland

Central Contacts

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Aleksi Reito, Assoc prof

Role: CONTACT

+358444729631

Satu Ylä-Mononen

Role: CONTACT

Facility Contacts

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Ville Ponkilainen, Assoc prof

Role: primary

Aleksi Reito, Assoc prof

Role: primary

Elina Ekman, MD, PhD

Role: primary

Other Identifiers

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R21010

Identifier Type: -

Identifier Source: org_study_id

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