A Prospective Study to Evaluate Continuous Positive Airway Pressure Devices to Reduce Pulmonary Dose
NCT ID: NCT05142358
Last Updated: 2026-02-02
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
8 participants
INTERVENTIONAL
2022-10-19
2026-01-28
Brief Summary
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Detailed Description
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Continuous positive airway pressure (CPAP) devices are commonly utilized for patients with obstructive sleep apnea. However, through the use of continuous pressure, lung volumes are increased. Preliminary data in patients undergoing breast radiation as well as lung radiation has demonstrated the safety and feasibility of such an approach, demonstrating increased lung volumes with decreases in heart dose6-8. Additional potential advantages of CPAP include increased ease of use for patients and the potential for cost savings as compared to traditional respiratory management techniques.
This prospective study is to allow for the collection and assessment of data on patients with left-sided breast cancer or undergoing lung SBRT utilizing CPAP. This will allow for the assessment of lung doses with and without CPAP as well as cardiac doses. No additional changes to our standard of care breast or lung radiation will occur. With respect to the safety profile, CPAP is commonly used with limited toxicity concerns. The potential benefit of CPAP has reduced lung and heart doses and, consequently, radiation-related toxicities.
Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
SUPPORTIVE_CARE
NONE
Study Groups
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Lung SBRT
Participants will come in for their regularly scheduled radiation planning and treatment. Participants will undergo three scans (with and without DIBH (i.e., free-breathing), with CPAP). Participants will also use the CPAP device before the CT scan, for which they will be educated and trained.
Continuous Positive Airway Pressure
Use of CPAP device at the start of treatment planning.
Deep inspiratory breath hold
Treatment during breath holds leads to longer treatment times for patients and radiation oncology departments
Free Breath
Regular breathing
left-sided breast cancer
Participants will come in for their regularly scheduled radiation planning and treatment. Participants will undergo three scans (with and without DIBH (i.e., free-breathing), with CPAP). Participants will also use the CPAP device before the CT scan, for which they will be educated and trained.
Continuous Positive Airway Pressure
Use of CPAP device at the start of treatment planning.
Deep inspiratory breath hold
Treatment during breath holds leads to longer treatment times for patients and radiation oncology departments
Free Breath
Regular breathing
Interventions
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Continuous Positive Airway Pressure
Use of CPAP device at the start of treatment planning.
Deep inspiratory breath hold
Treatment during breath holds leads to longer treatment times for patients and radiation oncology departments
Free Breath
Regular breathing
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Patients must be undergoing left breast/chest wall radiation with or without regional nodal irradiation
* Patients undergoing lung SBRT
* Primary lung cancers
* Metastatic lung tumors
Exclusion Criteria
* Patients who are unable to tolerate the CPAP device
18 Years
ALL
No
Sponsors
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Varian Medical Systems
INDUSTRY
Case Comprehensive Cancer Center
OTHER
Responsible Party
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Principal Investigators
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Sheeh Cherian, MD
Role: PRINCIPAL_INVESTIGATOR
Cleveland Clinic Taussig Cancer Institute, Case Comprehensive Cancer Center
Locations
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Cleveland Clinic Taussig Cancer Institute, Case Comprehensive Cancer Center
Cleveland, Ohio, United States
Countries
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Other Identifiers
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CASE5Y21
Identifier Type: -
Identifier Source: org_study_id
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