Breast Radiotherapy Audio Visual Enhancement for Sparing the Heart

NCT ID: NCT02881203

Last Updated: 2023-07-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

45 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-09-15

Study Completion Date

2022-09-30

Brief Summary

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This study investigates the Breathe Well device to test whether it is superior to the existing treatment standard of the Varian Realtime Position Management (RPM) system in assisting patients with deep inspiration breath hold.

Detailed Description

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Recent studies have demonstrated an increased risks of cardiac disease in breast cancer radiotherapy patients. For patients diagnosed \<50 years old, the risks for cardiovascular diseases/events were increased by 24-82% comparing left and right breast radiotherapy. The deep inspiration breath hold (DIBH) technique addresses this problem by reducing the heart dose by up to half, thus potentially reducing the increased rate of major coronary events by 20%. Providing patients with visual feedback in addition to audio guidance has been demonstrated to improve the reproducibility of the DIBH technique by 95% and stability by 80%.

Breathe Well is a new audiovisual feedback device that may increase the accuracy and workflow of implementing DIBH for breast cancer patients.

Conditions

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Breast Cancer

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Breathe Well + RPM

Participants will receive Breathe Well audiovisual feedback in addition to the RPM system

Group Type EXPERIMENTAL

Breathe Well

Intervention Type DEVICE

Breathe Well is an audiovisual biofeedback device used to assist patients to regulate their breathing whilst undergoing radiation treatment.

RPM

Intervention Type DEVICE

Varian Real-time Position Management (RPM) system

RPM

Varian's RPM system is the current standard of care at Royal North Shore Hospital where this trial is to be run.

Group Type ACTIVE_COMPARATOR

RPM

Intervention Type DEVICE

Varian Real-time Position Management (RPM) system

Interventions

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Breathe Well

Breathe Well is an audiovisual biofeedback device used to assist patients to regulate their breathing whilst undergoing radiation treatment.

Intervention Type DEVICE

RPM

Varian Real-time Position Management (RPM) system

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Left-sided breast cancer patients (invasive and in situ)
* Supine positioning of the patients.
* Ability to perform a ≥20s breath hold
* \>18 years old
* An ECOG score in the range of 0 to 2
* Able to give written informed consent and willingness to participate and comply with the study
* Patients must be able to read and complete questionnaires in English

Exclusion Criteria

* Involvement or at risk regional lymph nodes
* Pregnant / lactating women
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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University of Sydney

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Gillian Lamoury, Medicine

Role: PRINCIPAL_INVESTIGATOR

Royal North Shore Hospital

Locations

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Royal North Shore Hospital

St Leonards, New South Wales, Australia

Site Status

Countries

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Australia

References

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Byrne HL, Steiner E, Booth J, Lamoury G, Morgia M, Richardson K, Ambrose L, Makhija K, Stanton C, Zwan B, Bromley R, Atyeo J, Silvester S, Plant N, Keall P. BRAVEHeart: a randomised trial comparing the accuracy of Breathe Well and RPM for deep inspiration breath hold breast cancer radiotherapy. Trials. 2023 Feb 22;24(1):132. doi: 10.1186/s13063-023-07072-y.

Reference Type DERIVED
PMID: 36814310 (View on PubMed)

Other Identifiers

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BRAVEHeartV1

Identifier Type: -

Identifier Source: org_study_id

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