Cyberknife® Partial Breast Irradiation (PBI) for Early Stage Breast Cancer

NCT ID: NCT01162200

Last Updated: 2020-08-20

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE1
• Total Enrollment: 75 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2010-10-04
• Study Completion Date: 2015-12-28

Brief Summary

By using stereotactic body radiation therapy (SBRT) delivered with the Cyberknife system®, the current protocol attempts to mimic or improve the excellent local control rates seen in treatment of early stage breast cancer while attempting to increase convenience, limit invasiveness, decrease toxicity, and improve cosmesis compared to other methods of radiation treatment.

Conditions

Early Stage Breast Cancer

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Stereotactic Body Radiation Therapy

SBRT dose per fraction

Group Type: OTHER

Stereotactic Body Radiation Therapy

Intervention Type: RADIATION

3 dose cohorts. Patients in each dose cohort will all be treated as a single group for dose escalation. The starting dose for the dose escalation portion will be 6 Gy per fraction for 5 fractions (total dose = 30 Gy). Subsequent cohorts of patients will receive an additional 0.5 Gy per treatment (total 2.5 Gy per escalation).

Interventions

Stereotactic Body Radiation Therapy

3 dose cohorts. Patients in each dose cohort will all be treated as a single group for dose escalation. The starting dose for the dose escalation portion will be 6 Gy per fraction for 5 fractions (total dose = 30 Gy). Subsequent cohorts of patients will receive an additional 0.5 Gy per treatment (total 2.5 Gy per escalation).

Intervention Type: RADIATION

Other Intervention Names

SBRT

Eligibility Criteria

Inclusion Criteria

• DCIS or invasive ductal, medullary, papillary, mucinous (colloid), or tubular histologies.
• Eligible patients must have appropriate staging studies identifying them as AJCC stage T1 or T2 (≤3 cm) treated with lumpectomy and axillary node dissection with at least 6 nodes sampled or sentinel node biopsy. Patients with up to 3 positive nodes without microscopic or macroscopic evidence of extracapsular extension are eligible.
• The patient's Zubrod performance status must be 0-2.
• Patients must be ≥ 18 years of age.
• If chemotherapy is planned, it must begin no earlier than two weeks following completion of radiation therapy.
• Unifocal breast cancer (no evidence of gross multifocal disease, multicentric, or bilateral disease.
• Negative margins after lumpectomy (re-excision for initial positive margins is allowed-negative margins defined as >2 mm clear of tumor in all directions).
• Negative post- lumpectomy mammography if malignancy-associated microcalcifications were initially present.
• The target lumpectomy cavity must be clearly delineated.
• Patients must complete appropriate pretreatment evaluation, including post-lumpectomy mammogram if microcalcifications were initially present to confirm complete removal.

Exclusion Criteria

• Evidence of suspicious microcalcifications in the breast prior to start of radiation.
• Patients with history of collagen vascular disease, specifically dermatomyositis with a CPK level above normal or active skin rash, systemic lupus erythematosis, or scleroderma.
• Patients with 4 or more histologically positive axillary nodes if axillary dissection is performed.
• Patients with distant metastases.
• Patients with invasive or extensive in-situ lobular carcinoma or non-epithelial breast malignancies such as sarcoma or lymphoma.
• Patients with multicentric gross disease defined as tumors in different quadrants of the breast or tumor separated by at least 4 cm or other clinically or radiographically suspicious areas in the ipsilateral breast unless confirmed to be negative for malignancy or biopsy.
• Patients must not have any palpable or radiographically suspicious ipsilateral or contralateral axillary, supraclavicular, infraclavicular, or internal mammary nodes unless there is histologic confirmation that these nodes are negative for tumor.
• Any previously treated contralateral invasive breast carcinoma or synchronous contralateral breast carcinoma.
• Prior non-hormonal therapy or radiation therapy for the current breast cancer or hormonal therapy for > 28 days after diagnosis or refusal to discontinue hormonal therapy.
• Patients with Paget's disease of the nipple
• Patients with prior invasive malignancy (except non-melanomatous skin cancer) unless disease free for a minimum of 3 years (e.g., carcinoma in situ of the breast, oral cavity, or cervix are all permissible).
• Patients with severe, active co-morbidity.
• Patients with psychiatric or addictive disorders that, in the opinion of the investigator, would preclude obtaining informed consent.
• Patients who are pregnant or lactating.
• Previous breast radiation on either side or thoracic radiation on the ipsilateral side..

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 99 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: No

Sponsors

University of Texas Southwestern Medical Center

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Asal Rahimi, MD

Role: PRINCIPAL_INVESTIGATOR

UT Southwestern Medical Center Dallas

Locations

University of Texas Southwestern Medical Center

Dallas, Texas, United States

UT Southwestern Medical Center

Dallas, Texas, United States

Countries

United States

Other Identifiers

STU 072010-015

Identifier Type: -

Identifier Source: org_study_id