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Prone Breast Radiotherapy Treatment Planning Observational Study

NCT ID: NCT02237469

Last Updated: 2022-12-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

280 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-09-30

Study Completion Date

2023-12-31

Brief Summary

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The study purpose is to evaluate whether or not clinical characteristics of women with breast cancer can predict which position for radiation treatment, prone or supine, will be associated with a dosimetry gain. Dosimetry gain in this study means the lowest radiation dose to non-target organs (heart, lungs, contralateral breast), while giving the prescribed dose to tumor bed and ipsilateral breast.

Detailed Description

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Retrospectively identify women who received curative radiation treatment after breast conserving cancer surgery, in whom simulation in prone and in supine position was performed. Compare the treatment plans for doses to targets and to non-target organs, according to clinical parameters of body mass index, size of breast, location of tumor and side. Furthermore, evaluate whether a single CT slide is enough or not to predict a dosimetry advantage.

Conditions

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Breast Cancer Female

Keywords

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Breast cancer Breast conserving surgery. Radiotherapy. Treatment planning. Prone.

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

RETROSPECTIVE

Study Groups

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Prone and supine simulation

Women with breast cancer receiving simulation in prone and in supine position for adjuvant radiation treatment.

Prone and supine simulation

Intervention Type RADIATION

Treatment planning in the two positions.

Interventions

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Prone and supine simulation

Treatment planning in the two positions.

Intervention Type RADIATION

Eligibility Criteria

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Inclusion Criteria

* Breast conserving surgery
* Adjuvant radiation treatment
* Simulation done prone and supine

Exclusion Criteria

* Simulation in only one position
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Varian Medical Systems

INDUSTRY

Sponsor Role collaborator

Vincent Vinh-Hung

OTHER

Sponsor Role lead

Responsible Party

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Vincent Vinh-Hung

MD, PhD

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Vincent Vinh-Hung, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Genova

Locations

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Geneva University Hospitals

Geneva, , Switzerland

Site Status

Countries

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Switzerland

References

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Dipasquale G, Wang X, Chatelain-Fontanella V, Vinh-Hung V, Miralbell R. Automatic segmentation of breast in prone position: Correlation of similarity indexes and breast pendulousness with dose/volume parameters. Radiother Oncol. 2016 Jul;120(1):124-7. doi: 10.1016/j.radonc.2016.04.041. Epub 2016 May 10.

Reference Type BACKGROUND
PMID: 27178144 (View on PubMed)

Andrianarison VA, Laouiti M, Fargier-Bochaton O, Dipasquale G, Wang X, Nguyen NP, Miralbell R, Vinh-Hung V. Contouring workload in adjuvant breast cancer radiotherapy. Cancer Radiother. 2018 Dec;22(8):747-753. doi: 10.1016/j.canrad.2018.01.008. Epub 2018 Oct 12.

Reference Type BACKGROUND
PMID: 30322819 (View on PubMed)

Heymann S, Dipasquale G, Nguyen NP, San M, Gorobets O, Leduc N, Verellen D, Storme G, Van Parijs H, De Ridder M, Vinh-Hung V. Two-Level Factorial Pre-TomoBreast Pilot Study of Tomotherapy and Conventional Radiotherapy in Breast Cancer: Post Hoc Utility of a Mean Absolute Dose Deviation Penalty Score. Technol Cancer Res Treat. 2020 Jan-Dec;19:1533033820947759. doi: 10.1177/1533033820947759.

Reference Type BACKGROUND
PMID: 32940569 (View on PubMed)

Vinh-Hung V, Leduc N, Verellen D, Verschraegen C, Dipasquale G, Nguyen NP. The mean absolute dose deviation-A common metric for the evaluation of dose-volume histograms in radiation therapy. Med Dosim. 2020 Summer;45(2):186-189. doi: 10.1016/j.meddos.2019.10.004. Epub 2019 Nov 19.

Reference Type BACKGROUND
PMID: 31757715 (View on PubMed)

Wang X, Fargier-Bochaton O, Dipasquale G, Laouiti M, Kountouri M, Gorobets O, Nguyen NP, Miralbell R, Vinh-Hung V. Is prone free breathing better than supine deep inspiration breath-hold for left whole-breast radiotherapy? A dosimetric analysis. Strahlenther Onkol. 2021 Apr;197(4):317-331. doi: 10.1007/s00066-020-01731-8. Epub 2021 Jan 8.

Reference Type RESULT
PMID: 33416915 (View on PubMed)

Fargier-Bochaton O, Wang X, Dipasquale G, Laouiti M, Kountouri M, Gorobets O, Nguyen NP, Miralbell R, Vinh-Hung V. Prone versus supine free-breathing for right-sided whole breast radiotherapy. Sci Rep. 2022 Jan 11;12(1):525. doi: 10.1038/s41598-021-04385-3.

Reference Type RESULT
PMID: 35017568 (View on PubMed)

Other Identifiers

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HUG 13-184R

Identifier Type: -

Identifier Source: org_study_id