The Role of Genetic Factors in the Development of Idiopathic Scoliosis in the Kazakh Population

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

400 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-03-23

Study Completion Date

2023-01-20

Brief Summary

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The purpose of this study is to identify genetic determinants of susceptibility to idiopathic scoliosis . It will assist in predicting individual risks of disease progression and would help to clarify pathophysiologic mechanisms of idiopathic scoliosis

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Detailed Description

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Conditions

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Idiopathic Scoliosis

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Study Groups

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Experimental group:

patients with idiopathic scoliosis

SNP analysis of the DNA

Intervention Type GENETIC

SNP analysis of the DNA obtained from peripheral blood sample

Control group

patients without idiopathic scoliosis

SNP analysis of the DNA

Intervention Type GENETIC

SNP analysis of the DNA obtained from peripheral blood sample

Interventions

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SNP analysis of the DNA

SNP analysis of the DNA obtained from peripheral blood sample

Intervention Type GENETIC

Eligibility Criteria

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Inclusion Criteria

1. Persons with a doctor-confirmed diagnosis of idiopathic scoliosis;
2. Persons of Kazakh nationality, whose paternal and maternal grandparents are Kazakhs;
3. Hereditary history of scoliosis;
4. Persons who are able and willing to provide written informed consent;

Exclusion Criteria

1. Patients diagnosed with idiopathic scoliosis under 4 and over 40 years of age;
2. Representatives of the Kazakh ethnic group less than 3 generations;
3. No family history of bilateral idiopathic scoliosis;
4. Patients with an acute period of the inflammatory process (laboratory and clinical signs);
5. Persons who, in the opinion of the researcher, are mentally or legally incapacitated, which prevents obtaining informed consent;
6. Pregnant or lactating women;
7. Tuberculosis of any localization in the active phase and in history;
8. Severe and decompensated diseases of the liver and kidneys, cardiovascular system;
9. Severe and decompensated course of endocrine diseases;
10. Autoimmune diseases;
11. Systemic diseases;
12. Oncological diseases;

Minimum Eligible Age

4 Years

Maximum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No