The Role of Genetic Factors in the Development of Epilepsy in the Kazakh Population

NCT ID: NCT05088499

Last Updated: 2023-03-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

600 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-02-01

Study Completion Date

2023-01-20

Brief Summary

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This is a GWAS study that aims to identify possible candidate genes associate to epilepsy by exploring single nucleotide polymorphism (SNP) in a group of epilepsy, in the Kazakh population. The investigators hypothesize that the careful phenotyping of the subject sand matching with increase the power to find SNP significantly associate with epilepsy

Detailed Description

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A genome-wide association study (GWAS) is an approach used in genetics research to associate specific genetic variations with particular diseases. The method involves scanning the genomes from many different people and looking for genetic markers that can be used to predict the presence of a disease. Once such genetic markers are identified, they can be used to understand how genes contribute to the disease and develop better prevention and treatment strategies

Conditions

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Epilepsy

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Study Groups

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Experimental group:

Patients with epilepsy

DNA analysis

Intervention Type GENETIC

GWAS

Control group

Patients without epilepsy

DNA analysis

Intervention Type GENETIC

GWAS

Interventions

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DNA analysis

GWAS

Intervention Type GENETIC

Eligibility Criteria

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Inclusion Criteria

* Children with seizures, confirmed by EEG and no morphological damage to the brain, confirmed by MRI of the brain;
* The age of the patients is from 0 to 5 years;
* Persons of Kazakh nationality, whose paternal and maternal grandparents are Kazakhs;
* Children are parents or legal guardians who have given written informed consent.

Exclusion Criteria

* Children over 5 years old;
* Children whose parents, according to the researcher, are mentally or legally incapacitated, which prevents obtaining informed consent;
* Children with seizures with brain damage that cause epilepsy;
* Children of a non-Kazakh ethnic group.
Minimum Eligible Age

0 Years

Maximum Eligible Age

5 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Asfendiyarov Kazakh National Medical University

OTHER

Sponsor Role lead

Responsible Party

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Ildar Fakhradiyev

Head of the Laboratory of Experimental Medicine

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Altynshash Jaxybayeva

Role: STUDY_DIRECTOR

Astana Medical University, Nur-Sultan, Kazakhstan

Locations

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Altynshash Jaxybayeva

Almaty, , Kazakhstan

Site Status

Countries

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Kazakhstan

Other Identifiers

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1199

Identifier Type: -

Identifier Source: org_study_id

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