Comparison of Two Approaches of Quadratus Lumborum Block for Post-operative Analgesia in Radical Cystectomy

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-10-06

Study Completion Date

2024-09-25

Brief Summary

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To compare the postoperative analgesic effect of two ultrasound guided approaches of quadratus lumborum block (QLB) (anterior and intramuscular) for radical cystectomy.

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Detailed Description

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The quadratus lumborum block (QLB) is one of the abdominal wall block techniques used to anesthetize thoracolumbar nerves . The QLB technique was described initially by Blanco et al. in 2007 (not published), then reported initially by Kadam in 2013. Since then, QLB has evolved with the development of the ultrasound-guided nerve block. To date, several randomized controlled trials have reported effective postoperative analgesia, with non-intramuscular QLB for cesarean sections, laparoscopic gynecologic surgery and hip hemiarthroplasty .

The intramuscular QLB (QLBi) technique was first reported by. This approach is different from others in tubouchi for QLB; although the injection target sites of the other approaches are planes around the quadratus lumborum muscle, the intramuscular approach penetrates the fascia of the quadratus lumborum muscle, where local anesthetics are injected. Therefore, QLBi is relatively easier to perform compared with other QLB approaches.

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Conditions

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Quadratus Lumborum Block

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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Group 1 (QLBA) will include 30 patients

will receive ultrasound-guided anterior approach quadratus lumborum block

Group Type EXPERIMENTAL

US guided injection

Intervention Type PROCEDURE

using 2.5mg/kg of 0.25% bupivacaine diluted in a 20 mL syringe of normal saline , received ultrasound-guided quadratus lumborum.

Group 2 (QLBI)will include 30 patients.

received ultrasound-guided intramuscular quadratus lumborum.

Group Type EXPERIMENTAL

US guided injection

Intervention Type PROCEDURE

using 2.5mg/kg of 0.25% bupivacaine diluted in a 20 mL syringe of normal saline , received ultrasound-guided quadratus lumborum.

Interventions

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US guided injection

using 2.5mg/kg of 0.25% bupivacaine diluted in a 20 mL syringe of normal saline , received ultrasound-guided quadratus lumborum.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Age: 40-70years.

* BMI: 20-30 kg.m2
* Sex: both males and females.
* American Society of Anesthesiologists (ASA )physical status: I-III.
* Operation: radical cystectomy

Exclusion Criteria

* • Patient's refusal to participate in the study.

* known allergy to local anesthesia (LA),
* coagulopathy or thrombocytopenia,
* body mass index (BMI) above 30 kg .m 2, and infection at site of injection.
* Chronic pain syndromes,
* Prolonged opioid medication,
* Patients on regular use of analgesic or who received analgesic 24 h before surgery

Minimum Eligible Age

40 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No