Bilateral Ultrasound Guided Quadratus Lumborum Versus Lumbar Epidural Block on Postoperative Analgesia, and Inflammatory Response in Abdominal Surgery

NCT ID: NCT03958942

Last Updated: 2019-07-05

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 60 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2019-06-01
• Study Completion Date: 2020-03-01

Brief Summary

This study aims at comparing the effects of bilateral ultrasound-guided quadratus lumborum block versus lumbar epidural block on postoperative analgesia and inflammatory response following major lower abdominal cancer surgery.

Conditions

Postoperative Pain; Inflammatory Response

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: TREATMENT
• Blinding Strategy: QUADRUPLE

Study Groups

quadratus lumborum block

received pre-emptive ultrasound-guided quadratus lumborum block with 25 mL of 0.25% bupivacaine on each side of the abdominal wall before induction of GA.

Group Type: ACTIVE_COMPARATOR

Ultrasound quadratus lumborum block with bupivacaine 25%

Intervention Type: OTHER

echogenic needle will be inserted in-plane with the ultrasound beam in a posterior-to-anterior direction through the quadratus lumborum muscle until the ventral fascia of the muscle penetrated. At this point, the needle directed toward the fascial plan between the quadratus lumborum and the Psoas muscle

lumbar epideural block

received pre-emptive lumbar epidural block with 15 mL of 0.25% bupivacaine before induction of GA.

Group Type: ACTIVE_COMPARATOR

lumbar epideural block with bupivacaine 25%

Intervention Type: OTHER

lumbar epidural will be performed for patients in group II using a 16-gauge Touhy epidural needle by a median approach. The T12 - L1 or L1 - L2 interspaces will be chosen for the injection. The epidural space identified by the loss of resistance technique.

Interventions

Ultrasound quadratus lumborum block with bupivacaine 25%

echogenic needle will be inserted in-plane with the ultrasound beam in a posterior-to-anterior direction through the quadratus lumborum muscle until the ventral fascia of the muscle penetrated. At this point, the needle directed toward the fascial plan between the quadratus lumborum and the Psoas muscle

Intervention Type: OTHER

lumbar epideural block with bupivacaine 25%

lumbar epidural will be performed for patients in group II using a 16-gauge Touhy epidural needle by a median approach. The T12 - L1 or L1 - L2 interspaces will be chosen for the injection. The epidural space identified by the loss of resistance technique.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• ASA II, III
• Weight 50 - 85 kg.
• Scheduled for major lower abdominal cancer surgery (radical cystectomy, total abdominal hysterectomy).

Exclusion Criteria

• Patients with a history of relevant drug allergy.
• Coagulation disorders.
• Opioid dependence.
• Sepsis.
• Local infection at the vicinity of the block site.
• Patients with psychiatric illnesses that would interfere with perception and assessment of pain

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 60 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Assiut University

OTHER

Sponsor Role: lead

Responsible Party

Ahmad Mohammad Abd El-Rahman

assisstant professor of Anesthesia, ICU, and Pain Management

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

South Egypt Cancer Institute

Asyut, , Egypt

Site Status: RECRUITING

Countries

Egypt

Central Contacts

Ahmad M Abd El-Rahman, M.D.

Role: CONTACT

ahmad23679@gmail.com

00201149606060

Facility Contacts

Moaaz El tohamy

Role: primary

Other Identifiers

255

Identifier Type: -

Identifier Source: org_study_id