Anterior Quadratus Lumborum Block at the Lateral Supra-arcuate Ligament for Analgesia After Open Liver Surgery

NCT ID: NCT04668391

Last Updated: 2022-07-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

74 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-12-17

Study Completion Date

2021-07-02

Brief Summary

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This is a prospective, randomized, controlled, noninferiority trial for evaluating the efficacy of ultrasound-guided anterior quadratus lumborum block at the lateral supra-arcuate ligament versus thoracic epidural analgesia after open liver surgery.

Detailed Description

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Conditions

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Liver Surgery

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Quadratus lumborum block

Ultrasound-guided anterior quadratus lumborum block at the lateral supra-arcuate ligament.

Group Type EXPERIMENTAL

Ultrasound-guided anterior quadratus lumborum block at the lateral supra-arcuate ligament

Intervention Type PROCEDURE

Bilateral single-injection 20 ml 0.56% ropivacaine. Intravenous analgesia was started postoperatively and consisted of 1ug/ml sufentanil,2 ml/h with a 5-minute lockout period, a limited 12 ml/h dose.

Thoracic epidural analgesia

Thoracic epidural analgesia at the level of T7-10.

Group Type ACTIVE_COMPARATOR

Thoracic epidural analgesia

Intervention Type PROCEDURE

A thoracic epidural at the level of T7-10. Epidural infusion was started postoperatively and consisted of sufentanil (0.6ug/mL) and ropivacaine(0.2%) at 3ml/h.

Interventions

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Ultrasound-guided anterior quadratus lumborum block at the lateral supra-arcuate ligament

Bilateral single-injection 20 ml 0.56% ropivacaine. Intravenous analgesia was started postoperatively and consisted of 1ug/ml sufentanil,2 ml/h with a 5-minute lockout period, a limited 12 ml/h dose.

Intervention Type PROCEDURE

Thoracic epidural analgesia

A thoracic epidural at the level of T7-10. Epidural infusion was started postoperatively and consisted of sufentanil (0.6ug/mL) and ropivacaine(0.2%) at 3ml/h.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Age≥18 years
* ASA I-III
* Open liver surgery

Exclusion Criteria

* Contraindication to nerve block or epidural puncture
* Chronic use of opioids or NSAIDs
* Refused to participate in the study
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Zhejiang Cancer Hospital

OTHER

Sponsor Role lead

Responsible Party

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Huifang Jiang

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Huifang Jiang, M.D.

Role: PRINCIPAL_INVESTIGATOR

Zhejiang Caner Hospital

Locations

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Zhejiang Cancer Hospital

Hangzhou, Zhejiang, China

Site Status

Countries

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China

References

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Li H, Ma D, Liu Y, Wang Y. A transverse approach for ultrasound-guided anterior quadratus lumborum block at the lateral supra-arcuate ligament. Anaesthesia. 2020 Oct;75(10):1400-1401. doi: 10.1111/anae.15058. Epub 2020 Jun 24. No abstract available.

Reference Type BACKGROUND
PMID: 32578192 (View on PubMed)

Gu B, Zhou H, Lian Y, Zhou Y, He S, Xie K, Jiang H. Ultrasound-Guided Anterior Quadratus Lumborum Block at Lateral Supra-Arcuate Ligament vs Thoracic Epidural Analgesia after Open Liver Surgery: A Randomized, Controlled, Noninferiority Trial. J Am Coll Surg. 2022 Dec 1;235(6):871-878. doi: 10.1097/XCS.0000000000000354. Epub 2022 Nov 15.

Reference Type DERIVED
PMID: 36102582 (View on PubMed)

Other Identifiers

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IRB-2020-350

Identifier Type: -

Identifier Source: org_study_id

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