En Bloc TURBT With Collins Loop vs Conventional TURBT

NCT ID: NCT05027412

Last Updated: 2021-08-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

80 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-04-01

Study Completion Date

2023-06-30

Brief Summary

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This is a prospective, randomized, randomized and single-blind study in patients diagnosed with primary bladder CV. Patients diagnosed by cystoscopy of a bladder tumor and with indication for endoscopic surgical treatment, who meet the inclusion criteria, and who sign the Informed Consent (IC), will be randomized.

Detailed Description

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The main objective of the study is to assess the quality of the resection, defined as the presence of detrusor muscle in the resected tissue.

The secondary objetives are:

* Compare the surgical time, hospital stay, urinary catheterization time and incidence of complications.
* Compare tumor recurrence after one year of follow up.
* Determine the number of re-TURB as a consequence of the absence of muscle layer in the sample or artifacts (Tx)
* Establish the incidence of conversions as a consequence of difficulties in the technique or intraoperative bleeding.
* Compare the degree of satisfaction of the surgeon

Conditions

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Bladder Cancer Bladder Neoplasm Bladder Urothelial Carcinoma Bladder Cancer Stage Urothelial Carcinoma Recurrent

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

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En Bloc TURBT with Collins Loop

If the patient is randomized to the TURB group, it will be carried out with a Collins loop, with bipolar energy.

After randomization, demographic data (age, sex, exposure to tobacco, occupational risk), symptoms prior to randomization (micro or macrohematuria, LUTS) and laboratory data (urinary cytology, hemoglobin and serum creatinine) will be collected. Finally, the physical characteristics of the lesion will be noted in the cystoscopy immediately prior to the intervention: size, location (s) and appearance of the tumor. After the intervention, the type of procedure (TURB / TUB), the duration of the procedure from when the resector is inserted until the urinary catheter is placed, and complications according to the Clavien-Dindo scale will be recorded. In your first post-surgical check-up, the days of hospital stay and the time of bladder catheterization will be collected.

Group Type EXPERIMENTAL

En bloc TURBT Collins Loop

Intervention Type DEVICE

En bloc TURBT Collins Loop

Conventional TURBT

The TURB will be carried out with bipolar current according to the traditional technique.

Group Type ACTIVE_COMPARATOR

Conventional TURBT

Intervention Type DEVICE

Conventional TURBT

Interventions

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En bloc TURBT Collins Loop

En bloc TURBT Collins Loop

Intervention Type DEVICE

Conventional TURBT

Conventional TURBT

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* \>18 years old.
* Polypoid / sessile primary tumor.
* \< 3 tumors
* Tumor size 10 - 30 mm.

Exclusion Criteria

* \> 4 tumors
* Size of the largest tumor \<1 cm and\> 4 cm.
* Tumor located in the bladder dome.
* No visualization of the ureteral meatus.
* Flat or in situ tumor.
* Non-urothelial tumors.
* Clotting disorder or treatment with oral anticoagulants.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hospital Universitario de Fuenlabrada

OTHER

Sponsor Role lead

Responsible Party

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Berta Nasarre

Attending Physician

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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emilio f ripalda, MD

Role: PRINCIPAL_INVESTIGATOR

Hospital Universitario de Fuenlabrada

Locations

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Hospital Universitario de Fuenlabrada

Fuenlabrada, Madrid, Spain

Site Status RECRUITING

Countries

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Spain

Central Contacts

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emilio A ripalda, MD

Role: CONTACT

+34916006000 ext. 6185

Facility Contacts

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Hugo Otaola Arca, M.D., Ph.D.

Role: primary

+56 9 4108 9452

Other Identifiers

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URO

Identifier Type: -

Identifier Source: org_study_id

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