Active Surveillance vs in Office Fulguration for Low Grade Bladder Cancer Tumors

NCT ID: NCT05148728

Last Updated: 2021-12-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

120 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-12-15

Study Completion Date

2024-03-15

Brief Summary

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Biological behabiour of low grade bladder cancer tumors is well known. They have a very high rate of recurrences during their follow up but very low (less than 1%) risk of progression.

Until now, the gold standard of any bladder recurrence for this patients is performing an immediate transurethral ressection of the tumor.

This surgery has risk of complications and, due to the low risk of these subgroup of tumors, sometimes it becomes an overtreatment for the patients.

This is the reason why new conservative or less invasive surgeries are proposed to follow up and treat these patients.

Detailed Description

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Conditions

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Bladder Cancer

Keywords

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active surveillance fulguration bladder cancer

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Active surveillance

After a recurrence in patient with previous low grade bladder cancer tumor, strict follow up with cystoscopy and cytology, avoiding immediate surgery

Group Type NO_INTERVENTION

No interventions assigned to this group

endoscopic fulguration

After a recurrence in patient with previous low grade bladder cancer tumor, fulguration under local anesthesia and sedation will be performed using a flexible cystoscope and a monopolar electrode

Group Type ACTIVE_COMPARATOR

Endoscopic fulguration

Intervention Type PROCEDURE

already included. WE will use Storz monopolar device for fulguration

Interventions

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Endoscopic fulguration

already included. WE will use Storz monopolar device for fulguration

Intervention Type PROCEDURE

Other Intervention Names

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Active surveillance

Eligibility Criteria

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Inclusion Criteria

* Recurrent Ta-T1a (above muscularis mucosa) LOW GRADE bladder tumor
* Accept cystoscopy surveillance
* Main lession less than 10mm
* Less than 7 lesions
* Negative or low grade cytology
* No solid aspect

Exclusion Criteria

* previous High grade bladder cancer tumors
* previous Cis
* previous Upper Urinary Tract tumor
* previous pelvic radiotherapy
* hematuria
* meatal localisation
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Vall Hebron Insitut Recerca

NETWORK

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Fernando Lozano Palacio

Barcelona, , Spain

Site Status

Countries

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Spain

Facility Contacts

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Fernando FL Lozano, MD

Role: primary

Other Identifiers

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PR(AG)401/2021

Identifier Type: -

Identifier Source: org_study_id