Lung Volume Perception and Impact of a Cognitive Task on Ventilation in Hypermobile Ehlers-Danlos Syndrome.

NCT ID: NCT05000151

Last Updated: 2022-07-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

38 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-09-02

Study Completion Date

2022-05-19

Brief Summary

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Patients with hypermobile Ehlers-Danlos syndrome have respiratory and proprioceptive disorders. The aim of this study is to explore whether there is an alteration in lung volume perception in patients with hEDS compared to healthy subjects, and whether a cognitive task can influence ventilation control differently in subjects with hEDS than in healthy subjects.

Detailed Description

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Conditions

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Hypermobile Ehlers-Danlos Syndrome

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Patients

Hypermobile Ehlers-Danlos patients (n=21)

No interventions assigned to this group

Healthy subjects

Healthy subjects recruited from the clinic's staff (n=21) Age, Gender and BMI matched with hEDS patients

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* More than 18 years old
* Understanding French


* hEDS diagnosis


* Age (±5 years), Gender and BMI (±2.5kg/m²) matching

Exclusion Criteria

* Pregnancy


* Respiratory comorbidity independent of hEDS
* Previous participation in a rehabilitation programme at the clinic


* Known respiratory or proprioceptive pathology
* Hypermobility (evaluated with the Beighton score)
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Hakimi Adrien

OTHER

Sponsor Role lead

Responsible Party

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Hakimi Adrien

MCs, PT

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Cyrille Bergoin, MD

Role: PRINCIPAL_INVESTIGATOR

Clinique de la Mitterie

Patrick Mucci, Prof.

Role: STUDY_DIRECTOR

UREPSSS

Locations

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Clinique de la Mitterie

Lomme, , France

Site Status

Countries

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France

References

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Hakimi A, Bergoin C, De Jesus A, Hermand E, Fabre C, Mucci P. Impairment of lung volume perception and breathing control in hypermobile Ehlers-Danlos syndrome. Sci Rep. 2024 Apr 6;14(1):8119. doi: 10.1038/s41598-024-58890-2.

Reference Type DERIVED
PMID: 38582758 (View on PubMed)

Other Identifiers

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ProprioRespi

Identifier Type: -

Identifier Source: org_study_id

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