Changes in Tactile Perception in People With Segmental Exclusion Syndrome

NCT ID: NCT05650398

Last Updated: 2025-08-22

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 34 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2022-09-26
• Study Completion Date: 2025-02-15

Brief Summary

Segmental exclusion syndrome is characterised by the non-use or under-use of a limb segment, most oftenly reported in the distal part, following an injury, without affecting the central nervous system. This syndrome has an important negative impact on the daily life of affected subjects; however, it remains poorly studied, particularly in terms of pathophysiology, and its management is still not specific. Currently, the main pathophysiological hypothesis is an alteration of the afferences related to a dysfunction of the sensorimotor loop. An hypothesis is that this dysfunction could concern the level of tactile perception and that the damage to the distal light touch receptors could play a role in the pathophysiology. The protocol is based on the performance of tests that explore different aspects of light touch: passive, active, dynamic and static sensitivity.

Conditions

Upper Limb Exclusion Syndrom

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: PROSPECTIVE

Study Groups

Patients with exclusion

Evaluation of the tactile sensitivity of the excluded finger using different tests: Static and dynamic two-points discrimination tests, the Semmes-Weinstein monofilament test, grating orientation task and the bar test inspired by the study of Louw et al.

Realization of the same tests on the controllateral healthy finger.

No interventions assigned to this group

Control

Evaluation of the tactile sensitivity of the finger using different tests: Static and dynamic two-points discrimination tests, the Semmes-Weinstein monofilament test, grating orientation task and the bar test inspired by the study of Louw et al.

Realization of the same tests on the controllateral finger.

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• No history of upper limb involvement
• Confirmed diagnosis of segmental exclusion > 3 months after injury (2 items assigned to 400 points)
• Able to understand simple orders

Exclusion Criteria

• Central neurological involvement after the initial or pre-existing injury
• Truncal nerve damage
• Presence of psychiatric pathology
• Communication and/or comprehension disorders
• Presence of other pathology that may lead to sensory disorders (complicated diabetes, ductal syndrome, ...)

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Union de Gestion des Etablissements des Caisses d'Assurance Maladie - Nord Est

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Institut Régional de Médecine Physique et de Réadaptation

Nancy, , France

Countries

France

Other Identifiers

IRR-CLP-2022-9

Identifier Type: -

Identifier Source: org_study_id