Prone Position During ECMO in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Hypoxaemic Patient

NCT ID: NCT04995289

Last Updated: 2021-08-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

23 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-01-01

Study Completion Date

2021-01-30

Brief Summary

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Introduction:

The main manifestation of COVID-19 pneumonia is acute respiratory distress syndrome (ARDS), which in some cases can be more severe than intubation, extracorporeal membrane venous oxygenation (VV-ECMO) to ensure hematosis. Despite support from VV-ECMO, some patients may remain hypoxemic. One possible therapeutic procedure for these patients is the application of the prone position.

Objective:

The main aim of this study was to investigate the modification of the PaO2/FiO2 ratio, the compliance of the respiratory system in VV-ECMO with refractory hypoxemia. The secondary objective was to evaluate the safety and feasibility of the inclined position for ECMO.

Methods:

the investigators reviewed the electronic records and lists of all 23 COVID-19 patients. were placed for the first time in PP with an average duration of 16 h . patient characteristics, pre-ECMO characteristics, ventilator/ECMO settings, and changes in ventilator/ECMO settings and blood gas analysis before and after PP.

Detailed Description

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The main objective of the current study was to investigate the change in PaO2/FiO2 ratio, the compliance of the respiratory system in VV-ECMO patients with persistent hypoxemia. Measurements were taken before PP, 1 h after the start of the PP, at the end of the PP cycle.

The secondary objective of this study was to assess the safety and feasibility of emergency positioning for patients with severe ARDS during ECMO treatment.

Conditions

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SARS CoV 2 Infection Hypoxemic Respiratory Failure

Study Design

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Observational Model Type

CASE_CROSSOVER

Study Time Perspective

RETROSPECTIVE

Interventions

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Prone position on ECMO patient

blood gas analysis before and after PP

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Clinical diagnosis of SARS COV 2 infection complicated by ARDS, and needed a VV ECMO.
* patient who presented refractory hypoxemia during VV ECMO.

Exclusion Criteria

* patient who has received ECMO V-A or ECMO VV for reasons other than ARDS.
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Mohammed VI University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Younes Oujidi

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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younes Oujidi

Berkane, , Morocco

Site Status

Countries

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Morocco

Other Identifiers

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MohammedVIUH

Identifier Type: -

Identifier Source: org_study_id

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