Extubation in the Operating Room After Living Donor Liver Transplantation

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

277 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-03-01

Study Completion Date

2021-06-29

Brief Summary

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Duration of mechanical ventilation, length of intensive care unit stay, length of postoperative hospital stay, and the incidence rates of complications between the group with endotracheal tube extubation in the operating room (OR-EX) and those without (NOR-EX) in patients who underwent living-donor liver transplantation for end-stage liver failure are going to be compared. Through these results, it is investigated whether endotracheal tube extubation in the operating room is useful in reducing the length of stay in the intensive care unit and the hospital stay after surgery in patients who have undergone living-donor liver transplantation.

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Detailed Description

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Long-term mechanical ventilation after liver transplantation may increase the risk of complications such as pneumonia, sepsis, and multi-organ failure. Recent advances in surgical techniques and the introduction of short-acting anesthetics have accelerated the recovery of liver transplant recipients, and early extubation after liver transplantation is being proposed as a standard method. The results of a study on early extubation in patients undergoing liver transplantation suggested a reduction in the length of stay in the neutralizer room and predictors of early extubation. However, these studies are limited to males, and there is no study in which the definition of early extubation includes extubation in the operating room or extubation in the operating room within 1-3 hours of arrival in the intensive care unit.

Conditions

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Extubation in the OR After LDLT

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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OR-EX

the group with endotracheal tube extubation in the operating room in patients who underwent living-donor liver transplantation for end-stage liver failure

endotracheal tube extubation in the operating room

Intervention Type OTHER

endotracheal tube extubation in the operating room

NOR-EX

the group without endotracheal tube extubation in the operating room in patients who underwent living-donor liver transplantation for end-stage liver failure

No interventions assigned to this group

Interventions

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endotracheal tube extubation in the operating room

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Adult patients 18 years of age or older who underwent living-donor liver transplantation for end-stage liver failure

Exclusion Criteria

* A score of 26 or higher on the model for end-stage liver disease (MELD) scale
* In case of endotracheal intubation when entering the operating room
* If hepatic encephalopathy is stage 3 or higher at the time of admission to the operating room
* When the arterial blood partial pressure (PaO2)/inhaled oxygen fraction (FiO2) ratio is less than 200 on the Arterial Blood Gas Analysis (ABGA) before the end of the living liver transplantation operation
* Preoperative chest X-ray examination or chest computed tomography shows pulmonary edema
* If patients is diagnosed with hepatopulmonary syndrome before surgery

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No