Effects of Compression Mobilization in OA Patients

NCT ID: NCT04944056

Last Updated: 2021-09-05

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 39 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2021-06-21
• Study Completion Date: 2021-07-11

Brief Summary

The study Design was randomized control trial in which data was collected From Riphah Rehabilitation And Research Center and Pakistan Railway Hospital-IIMCT. Convenient sampling technique was used for data collection. 39 patients having knee osteoarthritis were recruited in this study. After taking consent from patients, patients were divided randomly into two groups through lottery method. The Experimental Group received compression mobilization with Conventional Physiotherapy (n = 19) and the Control group received Conventional Physiotherapy (n = 20). Research data was collected through structural questionnaire. the main variables were ROM, MMT, Muscle length and mBBS.

Detailed Description

Osteoarthritis (OA) is a disease which since long times is considered to be a "wear and tear" malfunctioning disease leading to a loss of cartilage. Osteoarthritis is considered as a "degenerative joint disease Osteoarthritis is a term used for disease in which destruction of cartilage is involved (articular), with a bone thickening (subchondral) and formation of new bone. . Joint swelling is also considered as one significant clinical feature of osteoarthritis attributes to inflammation. Osteoarthritis is one of the most common type in arthritis as well as the major cause of chronic musculoskeletal pain. In addition it is attributed to mobility disability in the elder or high aged population all over the world. If we have a glimpse of Asia, prevalence rate of knee osteoarthritis is believed to be higher in the elder population most probably in women. Susan et all conducted a mega level study related to symptomatic OA, where it has been observed that there is an increasing shift in the incidental rates of OA with the age. So, it was concluded that incidence related to knee OA in women limiting the age between 70-89, approached per year is 1% in women and they had the higher rates as compared to males, especially once they are over 50 years of age. Levelling-off or declining shift tends to occur for both groups approximately at the age of 80. Research says that in China, this prevailing rate of mentioned osteoarthritis disease is 7.50%, with a ratio of 10.9 & 13.6% in males and females respectively. Bangladesh and India reports 5.80 & 10.20% respectively. Now considering mainland of Pakistan, 28% urban whereas 25% rural population suffer this particular disease.

Women are likely to suffer more with the OA as compared to men and they also tend to undergo the disease of OA with more severity. The marked increase of OA in females at menopause stages has directed towards investigational hypothesis that hormonal imbalance factor may perform a significant role for the developing of OA. However, results appearing on estrogen effects, either it's endogenous or exogenous, on OA as revealed from various observational researches have been contradictory. In a randomize clinical trials(the Heart and Estrogen/Progestin Replacement Study) considering the group of elder postmenopausal females suffering from heart disease, none significant variation was observed in persistence of knee pain or any associated disability while comparing those undergoing estrogen plus progestin therapy or those taking placebo.

The prevalence of OA disease and joints patterns that are effected by OA possibly vary amongst the ethnic and racial groups. The frequency of Hand and Hip OA was found remarkably less in Chinese, concluded in the Beijing Osteoarthritis Study, in resemblance to whites researched under Framingham Study. it's important to mention that Chinese females observed under the Beijing Osteoarthritis Study had considerably high prevalence of both symptomatic knee OA and radiographic knee OA as compared to white females at Framingham Study. Results while having consideration of Johnston County Osteoarthritis Project have showed the prevalence of hip OA in African American females(23%) was similar to that in white ladies (22%), with a conclusion that prevalence was a bit higher in African American men (21%) than that in white.

Result of various studies showed that dietary factor is a subject of considerable interest related to OA affected individuals. Vitamin D is considered as most advantageous nutritional factor for OA patients. Insufficiency of this specified vitamin will lead to bones thinness, brittleness or any mishaps.

Corpulence (Obesity leading to overweight) have since long been predicted as the most potent risk factor to OA, especially knee OA. A more consistence and reliable evidence found is that the alarming effects occurs due to obesity are the risks of bi-lateral radiography and symptomatic hip OA. So, it is considered that application of increased loads on joints is probably a major cause, but not necessarily, a mechanism by which the obesity results into hip or knee OA. Whereas, an application of overloading the knee and hip joints could possibly directed towards synovial joint breakdown and failure of ligamentous as well as other structural support.

A lot many studies provides evidence that knee injury is surely one of the strongest factor for risking OA. Severe conditions of injury to joints structures, particularly mentioning the meniscal tear that requiring meniscectomy, or trans-articular fracture or anterior cruciate ligament injury; may these all results into increased risk involvement of OA development and also musculoskeletal symptomatology.

Repeated use of particular joints for work is marked with the increasing risk of OA. The risk factor involved in the development of knee OA was at least two times more for men whose consistency in jobs require both kneeling and carrying or squatness in a mid-life would definitely have more risk of developing OA by the nature of their commitments as compared to women whose job commitments do not offer these physical activities in common. Therefore, its a must mention that knee OA risks which are associated with squatness or kneeling are much higher amongst those who are overweighed or who are indulgent in lifting.

Conditions

Osteo Arthritis Knee

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Control Group

It includes ultrasound therapy, glides, exercises and home plan.

Group Type: ACTIVE_COMPARATOR

conventional physiotherapy

Intervention Type: OTHER

• Ultrasound therapy 3-4 minutes.
• Tibiofemoral AP and PA glides 1 set x10reps x 3 sets.
• Patellar glides 1 set x 5 reps x 3 sets.
• Quads isometrics 1 set x 10 reps.
• Hams self stretching 1 sets x 10 reps.

Home plan:

• Quads isometrics 1 set x 10 reps.
• Hams self stretching 1 sets x 10 reps.
• Active range of motion.

Experimental Group

It includes ultrasound therapy, glides, exercises, compression mobilization and home plan.

Group Type: EXPERIMENTAL

compression mobilization

Intervention Type: OTHER

• Ultrasound therapy 3-4 minutes.
• Tibiofemoral AP and PA glides 1 set x10reps x 3 sets.
• Patellar glides 1 set x 5 reps x 3 sets.
• Quads isometrics 1 set x 10 reps.
• Hams self stretching 1 sets x 10 reps.
• Compression mobilization 1 set x 10 reps x 3sets.

Home plan:

• Quads isometrics 1 set x 10 reps.
• Hams self stretching 1 sets x 10 reps.
• Active range of motion.

Interventions

conventional physiotherapy

• Ultrasound therapy 3-4 minutes.
• Tibiofemoral AP and PA glides 1 set x10reps x 3 sets.
• Patellar glides 1 set x 5 reps x 3 sets.
• Quads isometrics 1 set x 10 reps.
• Hams self stretching 1 sets x 10 reps.

Home plan:

• Quads isometrics 1 set x 10 reps.
• Hams self stretching 1 sets x 10 reps.
• Active range of motion.

Intervention Type: OTHER

compression mobilization

• Ultrasound therapy 3-4 minutes.
• Tibiofemoral AP and PA glides 1 set x10reps x 3 sets.
• Patellar glides 1 set x 5 reps x 3 sets.
• Quads isometrics 1 set x 10 reps.
• Hams self stretching 1 sets x 10 reps.
• Compression mobilization 1 set x 10 reps x 3sets.

Home plan:

• Quads isometrics 1 set x 10 reps.
• Hams self stretching 1 sets x 10 reps.
• Active range of motion.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Age Limit 30 to 60
• Unilateral OA Knee
• Moderate OA

Exclusion Criteria

• No Associated Bone Disease
• Lumber Radiculopathy
• Osteoporosis
• Any MSK Deformity

• Minimum Eligible Age: 30 Years
• Maximum Eligible Age: 60 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Mir Arif Hussain

INDUSTRY

Sponsor Role: lead

Responsible Party

Mir Arif Hussain

Research Head

Responsibility Role: SPONSOR_INVESTIGATOR

Principal Investigators

Shakeeba Shahzadi, MS-OMPT

Role: PRINCIPAL_INVESTIGATOR

Riphah International University

Locations

Riphah Rehabilitation And Research Center and Pakistan Railway Hospital-IIMCT

Islamabad, Capital, Pakistan

Countries

Pakistan

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Other Identifiers

Shakeeba Shahzadi 00189

Identifier Type: -

Identifier Source: org_study_id