Prevalence of Oral Lesions in COVID-19 Patients

NCT ID: NCT04917549

Last Updated: 2022-04-04

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 124 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2020-09-02
• Study Completion Date: 2021-06-10

Brief Summary

Recently, a new coronavirus disease 2019 (COVID-19) has appeared and caused an unprecedented pandemic which is considered as an urgent threat to health authorities worldwide. Several symptoms are observed which are fever, cough, shortness of breath, headache, runny nose, muscle pain, fatigue, arthralgia, sputum production, conjunctivitis, diarrhea. Susceptibility, genetics, systematic diseases, population, gender, and age are crucial considerations for the onset and progression of the viral infection. The patients suffering from asthma or pulmonary deficiency are at high risk of mortality. A metallopeptidase, angiotensin-converting enzyme 2 (ACE2) is considered as the functional receptor for SARS-CoV-2 and it was isolated from a COVID-19 patient. ACE2 was recognized in type I and type II alveolar epithelial cells in both nasal and oral mucosa, in the nasopharynx, in the smooth muscle cells and endothelium of vessels in the stomach and the skin, distinctly in the basal cell layer of the epidermis extending to the basal cell layer of hair follicles, and in the basal layer of the non-keratinizing squamous epithelium. In order to study the possible routes of SARS-CoV-2 infection on the oral mucosa, we investigated whether oral lesions mainly affect the tongue mucosa due to higher ACE2-expressing cell composition and proportion more than that in other oral tissues. Moreover, appearance of oral lesions were as a result of SARS-CoV-2 infection or as a side effect of certain drugs for COVID-19 treatment was evaluated.

Conditions

Oral Lesions; COVID-19; Angiotensin-converting Enzyme 2

Study Design

• Observational Model Type: OTHER
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

Patients diagnosed with COVID-19

detection of oral lesions

Intervention Type: OTHER

oral lesions in patient diagnosed with COVID-19

Interventions

detection of oral lesions

oral lesions in patient diagnosed with COVID-19

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• age > 18 years.
• laboratory-confirmed COVID-19 infection (reverse transcription-polymerase chain reaction, RT-PCR).

Exclusion Criteria

• patients without a laboratory-confirmed diagnosis of COVID-19 infection.
• patients with olfactory or gustatory dysfunctions before the epidemic.
• patients with some malignant neoplasms.
• patients with neurodegenerative disorders.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Kafrelsheikh University

OTHER

Sponsor Role: lead

Responsible Party

Dalia Rasheed Issa

principal invistigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Dalia R Issa, PhD

Role: PRINCIPAL_INVESTIGATOR

Kafrelsheikh University

Locations

Dalia Rasheed Issa

Kafr ash Shaykh, Kafr el-Sheikh Governorate, Egypt

Countries

Egypt

Other Identifiers

KD/04/20

Identifier Type: -

Identifier Source: org_study_id